老年慢性支气管炎急性发作期嗜酸细胞趋化因子及炎症介质水平变化及临床意义  

Changes in the Levels of Eosinophil Chemokines and Inflammatory Mediators During Acute Exacerbations of Chronic Bronchitis in the Elderly and Their Clinical Significance

作　　者：谢明英 杨源瑞 蔡羚琴 李龙心 熊覃 XIE Mingying;YANG Yuanrui;CAI Lingqin(The General Hospital of the Western Area Command, Sichuan Chengdu 610083, China)

机构地区：[1]西部战区总医院干部病房,四川成都610083 [2]四川省达州市中心医院放射科,四川达州635000

出　　处：《河北医学》2022年第5期759-763,共5页Hebei Medicine

基　　金：四川省卫生和计划生育委员会科研课题,(编号:18PJ151)。

摘　　要：目的:探究老年慢性支气管炎急性发作期嗜酸细胞趋化因子及炎症介质水平变化及临床意义。方法:选择本院2020年8月至2021年9月收治的186例老年慢性支气管炎患者作为研究组,以同期80例健康老年体检者为对照组,检测并比较两组的嗜酸细胞趋化因子及炎症介质水平。结果:研究组嗜酸细胞趋化因子(Eotaxin)、单核细胞趋化蛋白-1(MCP-1)水平高于对照组(P<0.05);研究组肿瘤坏死因子-α(TNF-α)、超敏C-反应蛋白(hs-CRP)、降钙素原(PCT)水平高于对照组(P<0.05);老年慢性支气管炎急性发作期患者Eotaxin、MCP-1水平高于慢性迁延期、缓解期患者(P<0.05);慢性迁延期患者Eotaxin、MCP-1水平高于缓解期患者(P<0.05);老年慢性支气管炎急性发作期患者TNF-α、hs-CRP、PCT水平高于慢性迁延期、缓解期患者(P<0.05);慢性迁延期患者TNF-α、hs-CRP、PCT水平高于缓解期患者(P<0.05)。结论:Eotaxin、MCP-1、TNF-α、hs-CRP、PCT的检测对老年慢性支气管炎急性发作期具有重要指示作用。Objective:To explore the changes and clinical significance of eosinophil chemokines and inflammatory mediators in elderly patients with acute attack of chronic bronchitis.Methods:A total of 186 elderly patients with chronic bronchitis(study group)and 80 healthy elderly people(control group)were selected between August 2020 and September 2021.The levels of eosinophil chemokines and inflammatory mediators in the two groups were tested and compared.Results:The levels of eosinophil chemokines and monocyte chemotactic protein-1(MCP-1)in study group were higher than those in the control group(P<0.05).The levels of tumor necrosis factor-α(TNF-α),high-sensitivity C-reactive protein(hs-CRP)and procalcitonin(PCT)in study group were higher than those in the control group(P<0.05).The levels of eotaxin and MCP-1 in elderly patients with acute attack of chronic bronchitis were higher than those in chronic protracted stage and remission stage(P<0.05).The levels of eosinophil chemokines and MCP-1 in chronic protracted stage were higher than those in remission stage(P<0.05).The levels of TNF-α,hs-CRP and PCT in elderly patients with acute attack of chronic bronchitis were higher than those in chronic protracted stage and remission stage(P<0.05).Conclusion:The detection of Eotaxin,MCP-1,TNF-α,hs-CRP and PCT has important indications in elderly patients with acute attack of chronic bronchitis.

关 键 词：老年慢性支气管炎 急性发作期 嗜酸细胞趋化因子 炎症介质 

分 类 号：R65[医药卫生—外科学]