呼出气一氧化氮检测在亚急性咳嗽临床诊治中的意义  

Significance of Exhaled Nitric Oxide in Clinical Diagnosis and Treatment of Subacute Cough

作　　者：楚辉[1] 张杰[1] CHU Hui;ZHANG Jie(Beijing Tiantan Hospital Affiliated to Capital Medical University, Beijing 100070, China)

机构地区：[1]首都医科大学附属北京天坛医院呼吸内科,北京100070

出　　处：《河北医学》2022年第5期847-852,共6页Hebei Medicine

基　　金：北京市临床重点专科项目经费资助,(编号:京卫医(2020)129号)。

摘　　要：目的:探讨呼出气一氧化氮(FeNO)检测在亚急性咳嗽临床诊治中的价值。方法:选择171例我院呼吸内科就诊的亚急性咳嗽患者进行呼出气一氧化氮检测,对结果进行分析。结果:171例患者平均FeNO值为36.89±12.35,其中47.95%的患者为正常,18.13%为中间水平,33.92%为高水平。171例患者中PIC患者62例,平均FeNO值为23.05±15.03,83.87%的患者为正常,14.52%为中间水平,1.61%为高水平;CVA患者58例,平均FeNO值为78.36±22.67,其中1.72%的患者为正常,8.62%为中间水平,89.66%为高水平;UACS患者36例,平均FeNO值为16.76±7.88,其中63.89%的患者为正常,33.33%为中间水平,2.78%为高水平;EB患者10例,平均FeNO值为42.75±13.72,其中10.00%的患者为正常,50.00%为中间水平,40.00%为高水平;其它患者5例,平均FeNO值为15.38±6.62,其中100.00%的患者为正常,0.00%为中间水平,0.00%为高水平。各组平均FeNO值比较,CVA组与PIC、UACS、EB及其它组相比P<0.05,有统计学意义。EB组与PIC、UACS及其它组比较,P<0.05,有统计学意义,PIC组与UACS及其它组比较,P>0.05,无统计学意义,UACS与其它组比较,P>0.05,无统计学意义。CVA及EB组患者经吸入激素布地奈德治疗后68例患者均有效,其中CVA患者25例(43.10%)好转,33例治愈(56.90%),有效率100%。EB组患者6例(43.10%)好转,4例(40.00%)治愈,有效率100%。两组总有效率100%。两组FeNO水平均明显下降,与治疗前FeNO值相比有明显统计学差异。结论:呼出气一氧化氮检测在亚急性咳嗽的临床诊治中具有重要价值。对咳嗽变异性哮喘、嗜酸粒细胞性支气管炎的诊断具有重要意义,对亚急性咳嗽的治疗具有指导意义。Objective:To investigate the clinical value of exhaled nitric oxide(FeNO)in the diagnosis and treatment of subacute cough.Methods:171 patients with subacute cough in respiratory medicine department of our hospital were selected to detect exhaled nitric oxide,and the results were analyzed.Results:The mean FeNO value of 171 patients was 36.89±12.35,of which 47.95%were normal,18.13%were intermediate and 33.92%were high.Among the 171 patients,there were 62 patients with pic,with an average FeNO value of 23.05±15.03.83.87%of the patients were normal,14.52%were intermediate and 1.61%were high;There were 58 patients with CVA,the mean FeNO value was 78.36±22.67,of which 1.72%were normal,8.62%were intermediate,and 89.66%were high;There were 36 patients with UACS,with an average FeNO value of 16.76±7.88,of which 63.89%were normal,33.33%were intermediate and 2.78%were high;There were 10 patients with EB,with an average FeNO value of 42.75±13.72,of which 10.00%were normal,50.00%were intermediate and 40.00%were high;There were 5 other patients with an average FeNO value of 15.38±6.62,of which 100.00%were normal,0.00%were intermediate and 0.00%were high.Compared with PIC,UACS,EB and other groups,the average FeNO value of CVA group was P<0.05,which was statistically significant.Compared with PIC,UACS and other groups,EB group had statistical significance(P<0.05).Compared with UACS and other groups,PIC group had no statistical significance(P>0.05).Compared with UACS and other groups,UACS had no statistical significance(P>0.05).68 patients in CVA and EB groups were effective after treatment with inhaled hormone budesonide.Among them,25 patients with CVA(43.10%)improved,33 patients were cured(56.90%),and the effective rate was 100%.In EB group,6 cases(43.10%)were improved,4 cases(40.00%)were cured,and the effective rate was 100%.The total effective rate of the two groups was 100%.The level of FeNO in the two groups decreased significantly,which was significantly different from that before treatment.Conclusion:The detection o

关 键 词：亚急性咳嗽 呼出气一氧化氮 咳嗽变异性哮喘 嗜酸粒细胞性支气管炎 上气道咳嗽综合征 感染后咳嗽 

分 类 号：R441.5[医药卫生—诊断学]