谷氨酰胺对脓毒症器官保护作用的研究进展  

Research Progress in Protective Effect of Glutamine on Organs during Sepsis

作　　者：胡志凯 范骏[1] HU Zhi-kai;FAN Jun(Department of Emergency,the Second Affiliated Hospital of Nanchang University,Nanchang 330006,China)

机构地区：[1]南昌大学第二附属医院急诊科,南昌330006

出　　处：《南昌大学学报（医学版）》2022年第2期83-86,106,共5页Journal of Nanchang University：Medical Sciences

基　　金：国家自然科学基金(81760340)。

摘　　要：脓毒症器官功能障碍是脓毒症患者治疗过程中面临的主要问题之一,维护和保护脓毒症患者器官功能有重要临床意义。作为一种在临床广泛使用的免疫营养素,谷氨酰胺可以有效保护脓毒症时器官的形态以及相应的功能,包括脑、心脏、肺、肝脏、肠道以及肾脏等一系列重要器官。及时补充谷氨酰胺可以减轻炎症反应、抑制炎症因子的释放,但氨酰胺的给药时机、给药途径和剂量还有待深入研究。Organ dysfunction during sepsis is one of the main problems in the treatment of septic patients.It is of great clinical significance to maintain and protect the organ function in septic patients.As a widely used immunonutrient in clinical practice,glutamine can effectively protect the morphology and corresponding functions of organs during sepsis,including brain,heart,lung,liver,intestinal tract and kidney.Timely supplementation with glutamine can reduce inflammatory response and inhibit the release of inflammatory factors.However,the timing,route and dose of glutamine administration need to be further studied.

关 键 词：脓毒症 谷氨酰胺 器官保护 炎症反应 炎症因子 

分 类 号：R459.7[医药卫生—急诊医学]