安五脂素在小鼠体内的药代动力学研究  

Pharmacokinetics of Anwulignan in Mice

作　　者：陈聪 李涵 冯彦博 林豪 敬舒[2] 王春梅[1] 李贺[1] 陈建光[1] 孙靖辉[1] CHEN Cong;LI Han;FENG Yanbo;LIN Hao;JING Su;WANG Chunmei;LI He;CHEN Jianguang;SUN Jinghui(Pharmacy College of Beihua University,Jilin 132013,China;Affiliated Hospital of Beihua University,Jilin 132011,China)

机构地区：[1]北华大学药学院,吉林吉林132013 [2]北华大学附属医院,吉林吉林132011

出　　处：《北华大学学报（自然科学版）》2022年第1期44-47,共4页Journal of Beihua University（Natural Science）

基　　金：吉林省教育厅科学技术研究项目(JJKH20210065KJ);吉林市科学技术研究项目(20200404054).

摘　　要：目的运用高效液相色谱法分析安五脂素在小鼠体内的药代动力学特征.方法给小鼠口服安五脂素(10 m g/kg)后,取不同时间点的血液和组织样本,通过高效液相色谱法测定安五脂素的含量,运用DAS软件计算药代动力学参数,分析安五脂素在体内的分布特征.结果给药后24 h仍能在小鼠体内血液中检测到安五脂素,并在各个组织器官内广泛分布.结论安五脂素在小鼠体内的停留时间较长,分布广泛,尤其在肝内大量富集,并在脑组织中含量较高,在体内的组织浓度高低分别为肝>心>脑>肾>肺>脾.Objective To study the pharmacokinetic characteristics of Anwulignan in mice by HPLC.Method Mice were orally administered with Anwulignan(10 mg/kg),blood and tissue samples were taken at different time points,and the content of Anwulignan was determined by HPLC.The pharmacokinetic parameters were calculated and analyzed by DAS software.The distribution characteristics of Anwulignan in the body were also analyzed.Results Anwulignan was still detected in the blood after 24 hours administration and widely distributed across tissues and organs.Conclusion Anwulignan has a longer residence time in mice body and is widely distributed,especially in the liver,and the content is higher in the brain tissue.The tissue concentration in the body is as follows:liver>heart>brain>kidney>lung>spleen.

关 键 词：安五脂素 华中五味子 药物代谢动力学 体内分布 

分 类 号：R285.5[医药卫生—中药学]