子宫内膜容受性检测对于反复种植失败的有效性研究及影响种植窗的临床因素分析  

The Effectiveness of Endometrial Receptivity Test for Repeated Implantation Failure and Analysis of Clinical Factors Affecting Implantation Window

作　　者：白云[1] 李蕾[1] 吴月蓉 钟兰萍[1] BAI Yun;LI Lei;WU Yuerong;ZHONG Lanping(Dept.of Reproductive Medicine,The 1st People’s Hospital of Yunnan&The Affiliated Hospital of Kunming University of Science and Technology,Kunming Yunnan 650032,China)

机构地区：[1]云南省第一人民医院/昆明理工大学附属医院生殖医学科,云南昆明650032

出　　处：《昆明医科大学学报》2022年第5期71-75,共5页Journal of Kunming Medical University

基　　金：云南省科技厅-昆明医科大学应用基础研究联合专项基金资助项目[2019FE001(-129)],云南省生殖妇产疾病临床医学中心开放基金资助项目[2019LCZXXF-SZ08,2021LCZXXF-SZ06,2021LCZXXF-SZ01]。

摘　　要：目的 利用子宫内膜容受性检测技术(endometrial receptivity test,ERT)对反复种植失败的患者实施个性化移植探讨该技术对于改善此类患者临床结局的有效性,同时分析影响内膜容受性的临床因素。方法 回顾性队列研究2020年12月至2021年11月期间于云南省第一人民医院生殖医学科诊断为反复移植失败病例的临床资料。根据是否接受子宫内膜容受性检测技术并按检测结果再次移植胚胎分为接受组和未接受组,比较2组间的临床结局。分析影响内膜容受性的临床因素。结果 接受组再次移植临床妊娠率及胚胎种植率均显著高于同期未接受组(P <0.05)。多因素回归分析显示,合并多囊卵巢综合征及发生卵泡未破裂黄素化是种植窗移位的影响因素(P <0.05)。结论 对于反复种植失败的患者,依据ERT检测结果移植能改善助孕结局;合并多囊卵巢综合征及发生卵泡未破裂黄素化是反复种植失败患者发生种植窗移位的危险因素。Objective To investigate the efficacy of personalized transplantation of Endometrial Receptivity Test(ERT) in improving the clinical outcome of patients with repeated implantation failure,and to analyze the clinical factors affecting Endometrial Receptivity.Methods A retrospective cohort study was conducted on the clinical data of patients diagnosed with repeated transplantation failure in the Reproductive Medicine Department of the First People’s Hospital of Yunnan from December 2020 to November 2021.The patients were divided into two groups according to whether or not they had undergone endometrial receptivity testing and retransplanted embryos according to the test results.The clinical outcomes were compared between the two groups.The clinical factors affecting the endometrial receptivity were[1] analyzed.Results The clinical pregnancy rate and embryo implantation rate in the receiving group were significantly higher than those in the non-receiving group(P < 0.05).Multivariate regression analysis showed that polycystic ovary syndrome and the occurrence of follicular unruptured luteinization were the influencing factors of implantation window shift(P < 0.05).Conclusion For patients with repeated implantation failure,transplantation can improve the outcome of assisted pregnancy according to ERT test results;Polycystic ovary syndrome and luteinization of unruptured follicles are risk factors for the implantation window displacement in patients with repeated implantation failure.

关 键 词：反复移植失败 子宫内膜容受性检测 体外受精-胚胎移植 

分 类 号：R711.6[医药卫生—妇产科学]