中西医结合治疗天津地区奥密克戎新型冠状病毒感染患者核酸转阴时间的影响因素分析  

Factor analysis of nucleic acid turning negative time of novel coronavirus Omicron infection patients treated by integrated traditional Chinese and Western medicine in Tianjin area

作　　者：孙宏源[1] 张圆[2] 石存忠[1] 刘晓亚[1] 赵桂峰[1] 赵强[1] 陈明虎[1] 武锃 吕仕超[1] 赵寻[3] 冯利民[3] 李强[3] 马妍[3] 张少强[3] 陈卓阳 张磊 李桂伟[1] 刘新桥[1] 毛静远[1] SUN Hongyuan;ZHANG Yuan;SHI Cunzhong;LIU Xiaoya;ZHAO Guifeng;ZHAO Qiang;CHEN Minghu;WU Zeng;LYU Shichao;ZHAO Xun;FENG Limin;LI Qiang;MA Yan;ZHANG Shaoqiang;CHEN Zhuoyang;ZHANG Lei;LI Guiwei;LIU Xinqiao;MAO Jingyuan(First Teaching Hospital of Tianjin University of Traditional Chinese Medicine,National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion,Tianjin 300381,China;Tianjin Hospital of ITCWM Nankai Hospital,Tianjin 300100,China;Second Teaching Hospital of Tianjin University of Traditional Chinese Medicine,Tianjin 300250,China;Tianjin Hospital,Tianjin 300211,China)

机构地区：[1]天津中医药大学第一附属医院,国家中医针灸临床医学研究中心,天津300381 [2]天津市南开医院,天津300100 [3]天津中医药大学第二附属医院,天津300250 [4]天津市天津医院,天津300211

出　　处：《天津中医药》2022年第5期551-555,共5页Tianjin Journal of Traditional Chinese Medicine

基　　金：国家重点研发计划“中医药现代化研究”重点专项(2018YFC1707503);国家科技应急攻关项目(2020YFC0841600);国家自然科学基金青年项目(82004505);天津市新型冠状病毒感染应急防控科技重大专项(20ZXGBSY00110);天津中医药大学第一附属医院新型冠状病毒肺炎专项科研课题(院2020001)。

摘　　要：[目的]探讨天津地区中西医结合治疗新型冠状病毒奥密克戎变种感染患者核酸转阴时间的影响因素。[方法]筛选新型冠状病毒奥密克戎变种感染患者的电子病历,提取住院号、性别、年龄、疫苗接种信息、既往慢性病情况、临床分型、合并前期症状、发病日期、入院日期、中医首次会诊日期、中医首诊辨证用药信息、核酸转阴日期等资料,采用回顾性分析方法,以患者核酸检测转阴时间作为结局观察指标,并以其平均值分组,比较组间临床特征指标差异,采用多元性线性回归分析评价结局的影响因素。[结果]筛选病历398例,剔除219例,纳入研究179例,分组后组间在合并慢性疾病、合并前期症状、入院时间差、中西医结合干预时间、中医证型分类等5项指标比较上差异具有统计学意义(P<0.05);多元线性回归分析显示合并慢性疾病、中西医结合干预时间、中医证型分类等3项与患者核酸转阴时间呈正相关(P<0.05)。[结论]合并慢性疾病、较晚中西医结合干预及中医辨证分类为兼杂证会延长新型冠状病毒奥密克戎变种感染患者核酸转阴时间。[Objective]To investigate the influencing factors of nucleic acid negative conversion time in patients infected with novel coronavirus Omicron variant treated with integrated Chinese and Western medicine in Tianjin area.[Methods]Screen electronic medical records of novel coronavirus Omicron variant infection patients,extract hospitalization number,gender,age,vaccination information,previous chronic diseases,clinical typing,combined early symptoms,onset date,admission date,date of first consultation of traditional Chinese medicine(TCM),dialectical drug use information of TCM at first diagnosis,nucleic acid negative conversion date,retrospective analysis method was adopted,the time of patients’nucleic acid test turning negative was used as the outcome observation index,and the patients were divided into groups with the mean value.The differences of clinical characteristic indexes between groups were compared.Multivariate linear regression analysis was used to evaluate the influencing factors of outcome.[Results]The 398 cases of medical records were screened,219 cases were excluded,and 179 cases were included in the study.After grouping,there were statistically significant differences between groups in the comparison of indicators such as complicated chronic diseases,complicated early symptoms,time difference between admission,intervention time of integrated traditional Chinese and Western medicine,and classification of TCM syndromes(P<0.05).Multiple linear regression analysis showed that there was a positive correlation between the time of nucleic acid conversion and chronic diseases,the intervention time of integrated traditional Chinese and Western medicine,and the classification of TCM syndromes(P<0.05).[Conclusion]Combined with chronic diseases,late intervention of integrated Chinese and Western medicine and dialectical classification of Chinese medicine as mixed syndromes can prolong the negative nucleic acid conversion time of patients infected with novel coronavirus Omicron variant.

关 键 词：天津地区 新型冠状病毒 奥密克戎变种 中西医结合 核酸转阴时间 

分 类 号：R563.1[医药卫生—呼吸系统]