右美托咪定复合丙泊酚静脉靶控输注在无痛人流中的应用价值及对预后结局的影响  

Application value of dexmedetomidine combined with propofol intravenous target controlled infusion in painless induced abortion and its effect on prognosis

作　　者：颜雪 熊彦青 郭小菊 YAN Xue;XIONG Yanqing;GUO Xiaoju(Department of Anesthesiology,the First Hospital of Nanchang,Nanchang,Jiangxi,330000,China;Operating Room,the First Hospital of Nanchang,Nanchang,Jiangxi,330000,China)

机构地区：[1]南昌市第一医院麻醉科,江西南昌330000 [2]南昌市第一医院手术室,江西南昌330000

出　　处：《当代医学》2022年第14期115-117,共3页Contemporary Medicine

基　　金：江西省卫生健康委科技计划(SKJP220200265)。

摘　　要：目的探讨右美托咪定复合丙泊酚静脉靶控输注(TCI)在无痛人流中的应用价值及对预后结局的影响。方法选取2019年1月至2020年8月于本院接受无痛人流的106例患者作为研究对象,按照随机数字表法分为参照组和观察组,各53例。参照组给予芬太尼复合丙泊酚TCI,观察组给予右美托咪定复合丙泊酚TCI,比较两组麻醉起效时间、唤醒时间及麻醉前(T_(0))、麻醉后2 min(T_(1))、扩阴器置入时(T_(2))、扩宫颈时(T_(3))、苏醒时(T_(4))的心率、收缩压及血氧饱和度。结果观察组麻醉起效时间、唤醒时间均短于参照组,差异有统计学意义(P<0.05)。T_(1)时,参照组心率低于T_(0)时(P<0.05);T_(1)~T_(4)时,观察组心率低于T_(0)时,且观察组低于参照组(P<0.05);T_(1)~T_(4)时,两组收缩压均低于T_(0)时,且观察组低于对照组(P<0.05);T_(1)~T_(4)时,两组血氧饱和度与T_(0)时比较差异有统计学意义(P<0.05),但组间各时间点比较差异无统计学意义。观察组不良反应发生率为11.32%,略高于参照组的7.55%,但两组不良反应发生率比较差异无统计学意义。结论右美托咪定复合丙泊酚TCI输注应用于无痛人流患者麻醉镇痛效果显著,麻醉起效、唤醒更快,可改善患者生命体征指标。Objective To investigate the application value of dexmedetomidine combined with propofol intravenous target controlled infusion(TCI) in painless induced abortion and its influence on prognosis. Methods 106 patients with painless induced abortion in our hospital from January2019 to August 2020 selected as the research subjects, and they were divided into reference group and observation group according to the random number table method, with 53 cases in each group. The reference group was given fentanyl combined with propofol TCI infusion, and the observation group was given dexmedetomidine combined with propofol TCI infusion, the onset time of anesthesia, wake-up time, and the heart rate, systolic blood pressure and blood oxygen saturation before anesthesia (T_(0)), 2 minutes after anesthesia (T_(1)), when the vaginal dilator was placed (T_(2)), when the cervix was dilated (T_(3)), and when awakening (T_(4)) were compared between the two groups. Results The onset time and wake-up time of anesthesia in the observation group were shorter than those in the reference group, and the difference was statistically significant (P<0.05). At T_(1), the heart rate of the reference group was lower than T_(0)(P<0.05);at T_(1)to T_(4), the heart rate of the observation group was lower than T_(0), and the observation group was lower than that of the reference group (P<0.05);at T_(1)to T_(4), the blood pressure in the the two groups was lower than that at T_(0), and the observation group was lower than the reference group (P<0.05). At T_(1)to T_(4), the blood oxygen saturation between the two groups was significantly different from that at T_(0)(P<0.05), but there was no statistically significant difference between the two groups at any time points. The incidence of adverse reactions in the observation group was 11.32%, slightly higher than 7.55% in the reference group, but there was no significant difference in the incidence of adverse reactions between the two groups. Conclusion Dexmedetomidine combined with propofol TCI infusio

关 键 词：无痛人流 右美托咪定 丙泊酚 静脉靶控 

分 类 号：R169.42[医药卫生—公共卫生与预防医学]