PRNs基因家族研究进展  

Research Progress on PRNs Gene Family

作　　者：樊锦瑞 王磊[1] 邹俊杰 FAN Jinrui;WANG Lei;ZOU Junjie(Biotechnology Research Institute,Chinese Academy of Agricultural Sciences,Beijing 100081,China)

机构地区：[1]中国农业科学院生物技术研究所,北京100081

出　　处：《生物技术进展》2022年第3期325-331,共7页Current Biotechnology

基　　金：国家自然科学基金项目(32070337,31801283);北京市自然科学基金项目(6192025);中央级公益性科研院所基本科研业务费专项(1610392020001)。

摘　　要：Pirins(简称PRNs、PIRs)是含有Cupin结构域的基因家族,属于功能各异的Cupin超家族成员之一。PRN蛋白的N端结构域含有金属离子结合位点,在原核和真核生物中高度保守。人hPRN可作为转录因子辅因子和氧化还原感受器参与癌症发生过程,是癌症治疗的潜在靶点。植物PRNs基因家族一般含有多个成员,其生物学功能尚未得到深入研究。概述了PRNs蛋白的基本结构及其生化特征,并综述了PRNs在人、微生物和植物中的生物学功能,以期为进一步解析水稻等作物中PRNs的功能提供一定线索,并为基因编辑等生物育种技术改良作物提供新的靶点。Pirins(PRNs,PIRs)are gene family containing cupin domain and belong to the functionally diversity cupin superfamily.The N-terminal domain of PRN contains a metal-ion binding site,which is highly conserved in prokaryotes and eukaryotes.Human hPRN could participate in cancer development as transcriptional regulator and redox sensor,suggesting that hPRN is a potential therapeutic target.In plants,there are several members in PRNs gene family,whereas their biological func⁃tions remain largely unknown.This paper outlined the basic structure and biochemical characteristic of PRNs,and reviewed the biological research progresses in human,microorganism and plants,in order to provide clues to clarify the PRNs molecular mechanism of crop such as rice,and provide target genes for the genetic improvement of crops production or adapation by gene editing and other molecular breeding techniques.

关 键 词：PRNs基因家族 金属离子 转录因子辅因子 氧化还原感受器 靶点 

分 类 号：Q501[生物学—生物化学]