脂肪间充质干细胞外泌体促进糖尿病创面愈合的研究进展  

Research advances on exosomes derived from adipose-derived mesenchymal stem cells in promoting diabetic wound healing

作　　者：王一希 陈俊杰[1] 岑瑛[1] 李正勇[1] 张振宇[1] Wang Yixi;Chen Junjie;Cen Ying;Li Zhengyong;Zhang Zhenyu(Department of Burns and Plastic Surgery,West China Hospital,Sichuan University,Chengdu 610041,China)

机构地区：[1]四川大学华西医院烧伤整形科,成都610041

出　　处：《中华烧伤与创面修复杂志》2022年第5期491-495,共5页Chinese Journal of Burns And Wounds

基　　金：国家自然科学基金面上项目(81871574);四川省科技计划(2020YFS0267);四川省卫生健康委科研课题(19PJ097)。

摘　　要：糖尿病创面形成的病理机制是导致糖尿病创面愈合困难的重要原因之一,难愈的糖尿病创面为患者及社会带来沉重负担。来源于干细胞的外泌体具有与干细胞相似的促组织再生能力及更多的临床优势,逐渐在创面愈合中发挥重要作用。近年来,诸多研究显示,脂肪间充质干细胞外泌体(ADSC-EXO)通过参与糖尿病创面愈合的各个过程,促进创面愈合。该文就导致糖尿病创面愈合困难的病理机制、ADSC-EXO促进糖尿病创面愈合的相关作用机制及其应用前景进行综述。Impaired healing of diabetic wounds is mainly attributed to its pathological mechanism,and refractory diabetic wounds bring heavy burdens to patients and society.Exosomes derived from stem cells possess the similar ability as stem cells in promoting tissue regeneration and more clinical advantages and are gradually playing important roles in wound healing.In recent years,researches have shown that exosomes derived from adipose-derived mesenchymal stem cells(ADSC-EXOs)can promote the healing of diabetic wounds by participating in various processes of wound healing.This article reviews the pathological mechanism leading to impaired healing of diabetic wounds,the related mechanism and the application prospect of ADSC-EXOs in promoting diabetic wound healing.

关 键 词：糖尿病 伤口愈合 外泌体 脂肪间充质干细胞 

分 类 号：R587.2[医药卫生—内分泌]