硝苯地平联合拉贝洛尔治疗对子痫前期患者脐动脉S/D值、胎儿血流动力学的影响  

Effects of nifedipine combined with labetalol on umbilical artery S/D value and fetal hemodynamics in patients with preeclampsia

作　　者：徐夏芝 潘维君 陈茂林 XU Xiazhi;PAN Weijun;CHEN Maolin(Department Obstetrics,Ma'anshan Maternal and Child Health Hospital,Ma'anshan Anhui 243000,China)

机构地区：[1]安徽省马鞍山市妇幼保健院产科,243000 [2]安徽省马鞍山市妇幼保健院生殖科,243000

出　　处：《中国妇产科临床杂志》2022年第3期248-250,共3页Chinese Journal of Clinical Obstetrics and Gynecology

基　　金：国家卫生计生委医药卫生科技发展项目(W2016CWAH02)。

摘　　要：目的 分析硝苯地平联合拉贝洛尔治疗子痫前期(PE)的疗效。方法 选取安徽省马鞍山市妇幼保健院PE患者110例,随机分为对照组(54例,予以硫酸镁及硝苯地平)、观察组(56例,在对照组基础上予以拉贝洛尔),比较两组临床疗效、治疗前后胎儿血流动力学相关参数,记录母婴结局、不良反应。结果 观察组治疗总有效率高于对照组(P <0.05);治疗后观察组24 h平均收缩压、平均舒张压、平均动脉压及脐动脉S/D值、动脉搏动指数(PI)、动脉血流阻力指数(RI)均低于对照组(P <0.05);观察组妊娠结局、新生儿结局不良发生率低于对照组,而出生后5 min Apgar评分高于对照组(均P <0.05);两组不良反应发生率差异无统计学意义(P>0.05)。结论 硝苯地平联合拉贝洛尔治疗PE可明显改善脐动脉血流动力学指标,有利于确保获得良好母婴结局。Objective To analyze the effects of nifedipine combined with labetalol in the treatment of preeclampsia(PE). Methods 110 patients with PE in Ma’anshan Maternal and Child Health Hospital were selected, and randomly divided into control group(54 cases, treated with magnesium sulfate and nifedipine) and observation group(56cases, treated with labetalol based on the treatment of control group). Clinical effects and fetal hemodynamic parameters were compared between the two groups. Maternal and neonatal outcomes, and adverse reactions were recorded.Results The total response rate in observation group was higher than that in the control group(P < 0.05). After treatment,the 24-hour mean systolic blood pressure, 24-hour mean diastolic blood pressure, 24-hour mean arterial pressure, umbilical artery S/D value, arterial pulsatility index(PI) and arterial blood flow resistance index(RI) of observation group were lower than those of the control group(P < 0.05). The incidences of adverse pregnancy outcomes and neonatal outcomes in observation group were lower than those in the control group, and 5 min Apgar score was higher(P < 0.05). The incidence rates of adverse reactions were similar in the two groups(P > 0.05). Conclusion Nifedipine combined with labetalol in the treatment of PE can significantly improve the hemodynamic indexes of umbilical artery, which is beneficial to ensure good maternal and infant outcomes.

关 键 词：硝苯地平 拉贝洛尔 子痫前期 脐动脉S/D值 胎儿血流动力学 

分 类 号：R714.244[医药卫生—妇产科学]