维持性血液透析患者腹主动脉钙化与血清细胞分裂周期蛋白42的相关性研究  

Correlation study of abdominal aortic calcification and serum cell division cycle 42 in maintenance hemodialysis patients

作　　者：巩雪 鹿恩邦 邢文秀 任彩霞 徐晓娜[3] 万美燕[2] Gong Xue;Lu Enbang;Xing Wenxiu;Ren Caixia;Xu Xiaona;Wan Meiyan(Dalian Medical University,Dalian 116044,China;Department of Nephrology,Qingdao Municipal Hospital,Qingdao 266011,China;The Central Laboratory of Qingdao Municipal Hospital,Qingdao 266011,China)

机构地区：[1]大连医科大学,大连116044 [2]山东省青岛市市立医院肾内科,青岛266011 [3]山东省青岛市市立医院中心实验室,青岛266011

出　　处：《中国综合临床》2022年第2期170-177,共8页Clinical Medicine of China

摘　　要：目的探究维持性血液透析(maintenance hemodialysis,MHD)患者腹主动脉钙化与血清细胞分裂周期蛋白42(cell division cycle 42,CDC-42)水平的相关性,并探究两者的影响因素。方法采用横断面研究方法,在青岛市市立医院血液净化中心选取2019年10月至2021年3月行MHD治疗至少6个月的患者112例。收集所有患者临床数据,应用腹部侧位X线平片计算其腹主动脉钙化积分(abdominal aortic calcification score,ACCs)。根据AACs分为无和轻度钙化组50例(0≤AACs<5分)、中重度钙化组62例(AACs≥5分)。血清CDC-42水平采用酶联免疫吸附试验进行检测。以中位血清CDC-42水平为界,划分为低CDC-42组56例和高CDC-42组56例。指标间的相关性采用Spearman相关性分析。MHD患者CDC-42升高和腹主动脉钙化的危险因素采用多因素Logistic回归分析进行探究,变量纳入采用进入法。应用线性回归分析探究指标间的多重共线性关系,血清CDC-42预测MHD患者腹主动脉钙化的临床价值应用受试者工作特征曲线进行评价。结果112例患者中91例(81.25%,91/112)存在腹主动脉钙化,血清CDC-42水平为466.56(335.56,623.57)ng/L。无和轻度钙化组患者CDC-42、AACs、年龄、透析龄、糖尿病肾病比例、糖化血红蛋白、碱性磷酸酶、甲状旁腺激素及血钙分别为347.77(291.20,419.53)ng/L、1.00(0.00,3.00)分、(57.18±6.25)岁、31.50(15.00,49.25)个月、34.00%(17/50)、(6.63±0.97)%、116.22(87.32,152.13)U/L、258.57(143.40,433.31)ng/L、(2.18±0.26)mmol/L,中重度钙化组分别为602.69(489.61,762.73)ng/L、10.00(7.00,16.25)分、(60.81±7.12)岁、49.00(18.00,67.00)个月、53.23%(33/62)、(7.07±1.20)%、144.34(99.71,201.76)U/L、336.57(230.63,506.00)ng/L、(2.28±0.26)mmol/L,两组间比较差异均有统计学意义[统计量值分别为6.99、9.11、2.83、2.45、4.14、2.08、2.04、2.16、1.99,均P<0.05]。低CDC-42组患者CDC-42、AACs、糖化血红蛋白及甲状旁腺激素分别为336.50(295.10,395.25)nObjective To explore the correlation between abdominal aortic calcification and serum cell division cycle 42(CDC-42)in maintenance hemodialysis(MHD)patients,and to explore the influencing factors of them.Methods A cross-sectional study was conducted in the Blood Purification Center of Qingdao Municipal Hospital,112 patients who underwent MHD for more than 6 months from October 2019 to March 2021 were selected.The abdominal aortic calcification score(ACCs)was calculated by reference to the abdominal lateral X flat tablets.According to AACS,50 cases were divided into no and mild calcification group(0≤AACS<5 points)and 62 cases were divided into moderate and severe calcification group(AACS≥5 points).The level of serum CDC-42 was detected by enzyme linked immunosorbent assay(ELISA).Taking the median serum CDC-42 level as the boundary,56 cases were divided into low CDC-42 group and high CDC-42 group.Spearman correlation analysis was used to analyze the correlation between indicators.The risk factors of elevated CDC-42 and abdominal aortic calcification in MHD patients were explored by multivariate logistic regression analysis,and the variables were included by entry method.Results In 112 patients,91 cases(81.25%,91/112)had abdominal aortic calcification,and the median serum CDC-42 level was 466.56(335.56,623.57)ng/L.CDC-42,AACs,age,dialysis age,diabetic nephropathy,glycosylated hemoglobin,alkaline phosphatase,parathormone and calcium in the no and mild calcification groups were 347.77(291.20,419.53)ng/L,1.00(0.00,3.00)points,(57.18±6.25)years,31.50(15.00,49.25)months,34.00%(17/50),(6.63±0.97)%,116.22(87.32,152.13)U/L,258.57(143.40,433.31)ng/L,(2.18±0.26)mmol/L,and in the moderate to severe calcification group were 602.69(489.61,762.73)ng/L,10.00(7.00,16.25)points,(60.81±7.12)years,49.00(18.00,67.00)months,53.23%(33/62),(7.07±1.20)%,144.34(99.71,201.76)U/L,336.57(230.63,506.00)ng/L,(2.28±0.26)mmol/L,with statistically significant differences between the two groups(The statistical values were 6.99,9.11,2.83,2.

关 键 词：细胞分裂周期蛋白42 血管钙化 腹主动脉 血液透析 

分 类 号：R692.5[医药卫生—泌尿科学]