Drug-related problems among inpatients of integrated traditional Chinese and western medicine department in China  

国内中西医结合病房的药物治疗相关问题研究

作　　者：Jie Yang Haiyang Meng Duolu Li Yanying Wang Zhaosen Gu Xiaojian Zhang 杨杰;孟海阳;李朵璐;王艳英;古兆森;张晓坚(郑州大学第一附属医院药学部,河南郑州450052;河南大学第一附属医院药学部,河南开封475000;郑州大学第一附属医院中西医结合科,河南郑州450052)

机构地区：[1]Department of Pharmacy,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,Henan,China [2]Department of Pharmacy,the First Affiliated Hospital of Henan University,Kaifeng 475000,Henan,China [3]Department of Traditional Chinese Medicine,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,Henan,China

出　　处：《Journal of Chinese Pharmaceutical Sciences》2022年第4期279-288,共10页中国药学（英文版）

基　　金：National Major New Drug Creation Project of China(Grant No.2020ZX09201-009)。

摘　　要：It is challenging to characterize the drug-related problems(DRPs)of patients treated by Integrated Traditional Chinese and Western Medicine(ITCWM),both locally and globally.In the present study,we aimed to assess DRPs and factors associated with their occurrence among inpatients of the ITCWM department in China.We retrospectively examined medication use in the ITCWM department,documented in Intelligent Management System Software for Critical Rational Administration of Drug.Various types of DRPs classification were performed based on the Pharmaceutical Care Network Europe(PCNE)classification tool V9.0,and associations of patient’s characteristics were analyzed.A total of 1606 DRPs were identified in 687 inpatients in this study.Problems and causes of DRPs,intervention,acceptance,and outcome of that were classified.PPI(21.7%),endogenous supplements(15.4%),and traditional Chinese medicine(8.7%)contributed to the significant proportion of drug categories associated with DRPs.Approximately half of the patients(47.6%)had at least one DRP.The top four categories of causes were“drug administered via the wrong route”(18.4%),“inappropriate combination”(16.7%),“too long duration of the treatment”(13.0%),and“inappropriate drug form”(12.1%).Total 63.6%of intervention was accepted and fully implemented.“EPP”and“hospital stay days≥10 d”characteristics were most likely to be significantly associated with DRPs.As a necessary review item,DRP was highly performed among inpatients of the ITCWM department.The work provided a benchmark for this population through the PCNE strategy.对中西医结合病房住院患者开展药物治疗相关问题的研究具有挑战性,我们希望明确此类患者的药物治疗相关问题发生情况及其影响因素。回顾性分析我院中西医结合病房相关资料,以欧洲药学监护联盟分类工具V9.0,对药物治疗问题进行确证和分类,并开展相关性分析。研究共纳入1606名患者,其中至少出现1种药物治疗相关问题的人数约占一半(47.6%)。问题主要来源于PPI(21.7%),内源性补充剂(15.4%)和中药制剂(8.7%)等。最常见的原因类别包括“给药途径错误”(18.4%)、“不适当联合用药”(16.7%)、“疗程过长”(13.0%)和“选择了不适当的用药剂型”(12.1%)。约63.6%的干预措施被接受和实施。出现问题最可能的相关因素是“过度联用药物”和“住院时间≥10天”。中西医结合病房药物治疗相关问题的存在较为普遍,在我们提供的策略基础上有必要开展进一步研究。

关 键 词：Drug-related problems DRPs Integrated traditional Chinese and western medicine department ITCWM 

分 类 号：R954[医药卫生—药学]