SARS-CoV-2 spike L452R mutation increases Omicron variant fusogenicity and infectivity as well as host glycolysis  

作　　者：Yanan Zhang Ting Zhang Yihui Fang Jie Liu Qinong Ye Lihua Ding 

机构地区：[1]Department of Medical Molecular Biology,Beijing Institute of Biotechnology,Beijing 100850,P.R.China [2]Faculty of Environment and Life,Beijing University of Technology,Beijing 100124,P.R.China

出　　处：《Signal Transduction and Targeted Therapy》2022年第4期964-966,共3页信号转导与靶向治疗（英文）

基　　金：the National Key Research and Development Program of China(2017YFA0505602);the National Natural Science Foundation(81930078,81872246,81802756,31470773 and 81773135);Military Medical Innovation Project(18CXZ047).

摘　　要：Dear Editor,The SARS-CoV-2 Omicron variant has rapidly displaced the Delta variant and spread across the world.The Omicron variant harbors over 60 mutations,and 15 of the mutations are located in the receptor-binding domain(RBD).1 Compared with parental virus and previous variants,the Omicron variant is characterized by decreased hospitalization rates and less severe disease in patients.

关 键 词：HARBOR OMI patients 

分 类 号：R563.1[医药卫生—呼吸系统]