儿童功能性便秘不同严重程度肠道菌群特点及胃肠激素水平变化  

Characteristics of intestinal bacteria and changes of gastrointestinal hormone levels in children with different severities of functional constipation

作　　者：王放 薛今俊[1] WANG Fang;XUE Jinjun(Department of Pediatrics,Tongde Hospital of Zhejiang Province,Hangzhou 310012,China)

机构地区：[1]浙江省立同德医院儿科,浙江杭州310012

出　　处：《中国现代医生》2022年第11期73-75,94,共4页China Modern Doctor

基　　金：浙江省中医药科技计划项目(2021ZA029)。

摘　　要：目的探讨儿童功能性便秘不同严重程度肠道菌群特点及胃肠激素水平变化。方法回顾性分析2019年1月至2020年10月浙江省立同德医院诊治的120例功能性便秘患儿的临床资料,将其设置为观察组,依据严重程度分为重度组(43例)与轻中度组(77例)。另选择同期进行体检的健康儿童120名为对照组。所有患者均检测肠道菌群数量及胃肠激素P物质(SP)、血管活性肠肽(VIP)、生长抑素(SS)、促胃动素(MTL)水平。结果①观察组患儿的乳杆菌、双歧杆菌数量明显少于对照组,大肠埃希菌明显多于对照组,差异均有统计学意义(P<0.05)。②轻中度组患儿的乳杆菌、双歧杆菌数量明显多于重度组,大肠埃希菌数量明显少于重度组,差异均有统计学意义(P<0.05)。③观察组患儿的SP、MTL水平明显低于对照组,VIP、SS水平明显高于对照组,差异均有统计学意义(P<0.05)。④轻中度组患儿的SP、MTL水平明显高于重度组,VIP、SS水平明显低于重度组,差异均有统计学意义(P<0.05)。结论儿童功能性便秘会造成肠道菌群失调及胃肠激素分泌不正常,同时病情越严重,肠道菌群失调及胃肠激素分泌不正常越明显。Objective To investigate the characteristics of intestinal bacteria and changes in gastrointestinal hormone levels in children with different severities of functional constipation.Methods The clinical data of 120 children with functional constipation diagnosed and treated in Tongde Hospital of Zhejiang Province from January 2019 to October 2020 were retrospectively analyzed and set as the observation group.According to the severity,the patients in the observation group were divided into the severe group(43 cases)and the mild to moderate group(77 cases).Another 120 healthy subjects who underwent physical examination during the same period were selected as the control group.The number of intestinal bacteria and the levels of gastrointestinal hormone substance P(SP),vasoactive intestinal skin(VIP),somatostatin(SS),and motilin(MTL)were measured in all patients.Results①The number of Lactobacillus and Bifidobacterium in the observation group was significantly less than in the control group.The number of Escherichia coli was significantly more than that in the control group.The differences were statistically significant(P<0.05).②The number of Lactobacillus and Bifidobacterium in the mild to the moderate group was significantly more than that in the severe group.The number of Escherichia coli was significantly less than that in the severe group.The differences were statistically significant(P<0.05).③The SP and MTL levels of the children in the observation group were significantly lower than those in the control group.The VIP and SS levels were significantly higher than those in the control group.The differences were statistically significant(P<0.05).④The SP and MTL levels of the children in the mild to moderate group were significantly higher than those in the severe group.The VIP and SS levels were significantly lower than those in the severe group.The differences were statistically significant(P<0.05).Conclusion Functional constipation in children may cause intestinal flora imbalance and abnormal gastrointestin

关 键 词：功能性便秘 儿童 肠道菌群 胃肠激素 严重程度 

分 类 号：R725.7[医药卫生—儿科]