急性脑梗死合并代谢综合征患者炎症因子、血凝指标的变化  

Changes of inflammatory factors and blood coagulation indexes in patients with acute cerebral infarction complicated with metabolic syndrome

作　　者：葛利娜 黄向东 GE Lina;HUANG Xiangdong(Department of Neurology,Wenzhou Central Hospital,Zhejiang Province,Wenzhou 325000,China)

机构地区：[1]浙江省温州市中心医院神经内科,浙江温州325000

出　　处：《中国现代医生》2022年第10期4-6,12,共4页China Modern Doctor

基　　金：浙江省医药卫生科技计划项目(2020RC033)。

摘　　要：目的 探讨急性脑梗死合并代谢综合征(MS)患者炎症因子、凝血-纤溶功能的变化。方法 选取2018年1月至2020年1月收治的急性脑梗死患者186例,根据是否合并MS分为脑梗死伴MS组(n=92)、脑梗死不伴MS组(n=94),另选取同期健康人群作为对照组(n=90)。比较三组IL-6、TNF-α、hs-CRP、PT、FIB、D-D等指标;比较两组脑梗死患者NIHSS评分。结果 脑梗死伴MS组IL-6、TNF-α、hs-CRP、FIB、D-D水平高于脑梗死不伴MS组及对照组,PT水平低于后者,差异均有统计学意义(P<0.05)。脑梗死不伴MS组IL-6、TNF-α、hs-CRP、FIB、D-D水平也高于对照组,差异有统计学意义(P<0.05)。脑梗死伴MS组NIHSS评分高于脑梗死不伴MS组,差异有统计学意义(P<0.05)。结论 脑梗死合并MS患者血浆炎症因子水平上升、凝血-纤溶平衡更倾向于凝血,且MS加重脑梗死患者神经功能缺损,需加强该类患者凝血指标和炎症状态的监测和干预。Objective To investigate the changes of inflammatory factors and coagulation-fibrinolytic function in patients with acute cerebral infarction complicated with metabolic syndrome(MS). Methods 186 patients with acute cerebral infarction from January 2018 to January 2020 were selected and divided into the group of cerebral infarction with MS(n=92) and the group of cerebral infarction without MS(n=94) based on whether they were complicated with MS. At the same time, healthy population at the same period was selected as the control group(n=90). The indexes of interleukin-6(IL-6), tumor necrosis factor-α(TNF-α), hypersensitive C-reactive protein(hs-CRP), prothrombin time(PT),fibrinogen(FIB) and D-dimer(D-D) were compared among the three groups, and the National Institute of Health Stroke Scale(NIHSS) scores were compared between the two groups of patients with cerebral infarction. Results The levels of IL-6, TNF-α, hs-CRP, FIB and D-D in the group of cerebral infarction with MS were higher than those in the group of cerebral infarction without MS and the control group, and the levels of PT were lower than those in the group of cerebral infarction without MS and the control group, all with statistically significant differences(P <0.05).Meanwhile, the levels of IL-6, TNF-α, hs-CRP, FIB and D-D in the group of cerebral infarction without MS were higher than those in the control group, with statistically significant differences(P<0.05). The NIHSS score in the group of cerebral infarction with MS was higher than that in the group of cerebral infarction without MS, with statistically significant differences(P<0.05). Conclusion Patients with cerebral infarction complicated with MS have increased plasma inflammatory factor levels, and coagulation-fibrinolysis balance is more inclined to coagulation. MS can aggravate neurological deficits in patients with cerebral infarction, therefore, it is necessary to strengthen monitoring and intervention of coagulation indexes and inflammation status in patients with acute cerebral in

关 键 词：急性脑梗死 代谢综合征 炎症因子 血凝指标 

分 类 号：R725.6[医药卫生—儿科]