血必净对腹腔感染性休克预后的影响  

Effect of Xuebijing on the prognosis of abdominal septic shock

作　　者：林洁[1] 曾繁林[2] 杨慧娟 朱宏泉[1] 欧阳松茂[1] LIN Jie;ZENG Fanlin;YANG Huijuan;ZHU Hongquan;OUYANG Songmao(Intensive Care Unit,the First Affiliated Hospital of Gannan Medical College,Ganzhou 341000,China;Department of Hepatobiliary Surgery,the First Affiliated Hospital of Gannan Medical College,Ganzhou 341000,China;Department of Oncology,the First Affiliated Hospital of Gannan Medical College,Ganzhou341000,China)

机构地区：[1]赣南医学院第一附属医院重症医学科,江西赣州341000 [2]赣南医学院第一附属医院肝胆外科,江西赣州341000 [3]赣南医学院第一附属医院肿瘤科,江西赣州341000

出　　处：《中国现代医生》2022年第10期88-91,共4页China Modern Doctor

基　　金：江西省中医药科研课题项目(2019A139)。

摘　　要：目的 分析血必净对腹腔感染性休克预后的影响。方法 选择2019年9月至2020年12月赣南医学院第一附属医院ICU腹腔感染性休克患者共70例,采用数字表随机分为两组,每组各35例,对照组患者给予抗休克治疗和亚胺培南西司他丁抗感染治疗,观察组在对照组基础上加用血必净。比较两组患者的住院天数、治疗前后血清学炎症因子指标PCT、hs-CRP、白细胞计数、IL-2、IL-6、TNF-α、IFN-γ、IL-4、IL-10水平、并发症发生率及死亡率。结果 观察组的住院天数为(10.64±2.02)d,短于对照组的(12.13±3.11)d,差异有统计学意义(P<0.05)。观察组患者的并发症发生率5.71%,死亡率0,均显著低于对照组的28.57%、20.00%,差异有统计学意义(P<0.05)。治疗后观察组的血清学炎症因子指标PCT、hs-CRP、白细胞计数、IL-2、IL-6、TNF-α、IFN-γ水平显著低于对照组,而IL-4、IL-10水平显著高于对照组,差异有统计学意义(P<0.001)。结论 抗休克治疗和亚胺培南西司他丁抗感染治疗联合血必净对于腹腔感染性休克的治疗效果确切。Objective To analyze the effect of Xuebijing on the prognosis of abdominal septic shock. Methods A total of 70 patients with abdominal septic shock from September 2019 to December 2020 in our ICU were selected and randomly divided into two groups, 35 cases in each group. The patients in the control group were given anti-shock therapy and anti-infection therapy with imipenem and cilastatin. The observation group added Xuebijing on this basis. The length of hospital stay, serological inflammatory factor parameters PCT, hs-CRP, white blood cell count, IL-2 level,IL-6 level, TNF-α, IFN-γ, IL-4, IL-10, complication rate, and mortality before and after treatment were compared between the two groups. Results The length of hospital stay was(10.64 ± 2.02) days in the observation group, which was shorter than that of(12.13 ± 3.11) days in the control group, with significant difference(P<0.05). The total complication rate of 5.71% and mortality of 0 in the observation group were significantly lower than those of 28.57% and20.00% in the control group, and the differences was statistical significance(P<0.05). After treatment, the serological inflammatory factor indicators PCT, hs-CRP, white blood cell count, IL-6 level, TNF-α, IL-2 level, and IFN-γ in the observation group were significantly lower than those in the control group, while IL-4 and IL-10 were significantly higher than those in the control group, and the differences was statistical significance(P<0.001). Conclusion Antishock therapy and anti-infection therapy with imipenem and cilastatin combined with Xuebijing are effective in treating abdomina septic shock.

关 键 词：血必净 腹腔感染性休克 血清学炎症因子 死亡率 

分 类 号：R459.7[医药卫生—急诊医学]