白介素-10在大学生健康危险行为与抑郁症状关联中的中介作用  

Mediating role of IL-10 in the association between health-risk behaviors and depressive symptoms of college students

作　　者：翟爽 陶舒曼 伍晓艳[1,3] 杨娅娟 项建民[5] 徐永生[5] 邹立巍[1] 谢阳 李婷婷 陶芳标[1,3] Zhai Shuang;Tao Shuman;Wu Xiaoyan;Yang Yajuan;Xiang Jianmin;Xu Yongsheng;Zou Liwei;Xie Yang;Li Tingting;Tao Fangbiao(School of Public Health,Anhui Medical University,Hefei 230032,China;The Second Hospital of Anhui Medical University,Hefei 230601,China;MOE Key Laboratory of Population Health Across Life Cycle/NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract,Hefei 230032,China;School of Nursing,Anhui Medical University,Hefei 230601,China;School of Physical Education,Shangrao Normal University,Shangrao 334001,China)

机构地区：[1]安徽医科大学公共卫生学院,合肥230032 [2]安徽医科大学第二附属医院,合肥230601 [3]出生人口健康教育部重点实验室/国家卫生健康委配子及生殖道异常研究重点实验室,合肥230032 [4]安徽医科大学护理学院,合肥230601 [5]上饶师范学院体育学院,上饶334001

出　　处：《卫生研究》2022年第3期353-360,共8页Journal of Hygiene Research

基　　金：国家自然科学基金(No.81803257,81773455);出生人口健康教育部重点实验室开放课题(No.JK20205)。

摘　　要：目的分析大学生健康危险行为与抑郁症状间的关联性,探讨血浆白介素-10(interleukin-10,IL-10)水平在二者关联中的中介作用。方法于2019年4--5月在安徽省合肥市和江西省上饶市各招募1所大学的大一学生,并于6个月后追踪调查,最终纳入702人,运用美国青少年健康危险行为监测系统改编问卷和抑郁-焦虑-压力自评量表评估大学生的健康危险行为状况和抑郁症状,同时基线时检测血浆IL-10水平。采用单变量分析大学生健康危险行为与抑郁症状的关联性,二分类Logistic回归分析健康危险行为和血浆IL-10与抑郁症状的关联性,并使用中介模型探讨血浆IL-10水平在二者关联中的中介作用。结果基线时,男生报告抑郁症状检出率高于女生(χ^(2)=6.33,P=0.01);自评家庭经济状况较差(χ^(2)=7.31,P=0.03)和健康状况较差(χ^(2)=6.71,P=0.04)的大学生报告抑郁症状的检出率更高。基线报告体力活动水平较低(χ^(2)=19.09,P<0.01)、吸烟(χ^(2)=7.03,P<0.01)和睡眠障碍(χ^(2)=68.78,P<0.01)的大学生抑郁症状的检出率更高;大学生基线健康危险行为聚集与基线抑郁症状和随访抑郁症状呈正相关(P<0.01)。调整性别、家庭经济状况和健康状况后,回归模型显示,基线血浆IL-10与6个月后抑郁症状(OR=0.36,95%CI 0.18~0.72)均呈负相关。结构方程模型显示健康危险行为负向预测IL-10水平(β=-0.13,SE=0.04),IL-10负向预测抑郁症状(β=-0.09,SE=0.04),IL-10在健康危险行为与抑郁症状起中介作用。结论大学健康危险行为与抑郁症状存在正相关,基线血浆IL-10水平与6个月后抑郁症状呈负相关,基线IL-10水平在基线健康危险行为聚集与随访抑郁症状间存在部分中介效应。OBJECTIVE To examine the relationship between health-risk behaviors and depressive symptoms among college students,and explore the mediating role of plasma IL-10 level in the relationship between the two.METHODS Freshman students in two universities in Hefei City,Anhui Province and Shangrao City,Jiangxi Province were recruited between April and May 2019,and follow-up investigation was conducted 6 months later.Health risk behaviors were measured based on the Young Risk Behavior Surveillance System(YRBSS)questionnaire,and depressive symptoms was evaluated by using the Depression Anxiety Stress Scale(DASS-21)among college students at baseline and 6 months follow-up survey.Plasma interleukin-10(IL-10)level was measured at baseline.Univariate analysis was used to compare the correlation between health risk behaviors and depressive symptoms among college students.Binary Logistic regression analyzed the relationship between health risk behaviors,IL-10 and depressive symptoms.The mediation model was used to explore the mediating role of IL-10 levels in the association between health risk behaviors and depressive symptoms.RESULTS At baseline,boys reported a higher rate of depressive symptoms than that of girls(χ^(2)=6.33,P=0.01);higher rates of depressive symptoms were observed in students who were from a family with a low perceived economic status(χ^(2)=7.31,P=0.03)or in poor health(χ^(2)=6.71,P=0.04).Participants who reported low physical activity(χ^(2)=19.09,P<0.01),smoking(χ^(2)=7.03,P<0.01),and poor sleep quality(χ^(2)=68.78,P<0.01)at baseline were more likely to experience depressive symptoms.Multiple health-risk behaviors at baseline were positively correlated with depressive symptoms among college students.After adjusting gender,self-reported family economy and self-rated health,the regression model showed that plasma IL-10 at baseline was negatively associated with the prevalence of depressive symptoms(OR=0.36,95%Cl 0.18-0.72)and the incidence of depressive symptoms after 6 months(OR=0.20,95%CI 0.08-0.49).S

关 键 词：健康危险行为 白介素10 抑郁症状 纵向研究 大学生 

分 类 号：R181.37[医药卫生—流行病学] R395.6[医药卫生—公共卫生与预防医学]