2型糖尿病患者血清sICAM-1、PRL表达与颈动脉内膜中层厚度的相关性研究  

Correlation between Serum sICAM-1 and PRL Expression and Carotid Intima-media Thickness in Patients with Type 2 Diabetes Mellitus

作　　者：李丹 谭小红 郭菲 刘正 苏湖梅 LI Dan;TAN Xiaohong;GUO Fei;LIU Zheng;SU Humei(Department of Endocrinology,331 Hospital,Zhuzhou,Hunan Province,412002 China)

机构地区：[1]湖南省株洲市三三一医院内分泌科,湖南株洲412002

出　　处：《糖尿病新世界》2022年第6期6-10,共5页Diabetes New World Magazine

摘　　要：目的检测2型糖尿病患者血清细胞间粘附因子-1(sICAM-1)、泌乳素(PRL)表达水平,探讨其与颈动脉内膜中层厚度(IMT)的相关性。方法选取2018年10月—2019年10月112例2型糖尿病患者展开分析研究,其中60例合并颈动脉粥样硬化患者为CA组,52例未合并颈动脉粥样硬化患者为对照组。收集两组患者临床资料,采用酶联免疫吸附(ELISA)法检测患者血清sICAM-1、PRL水平,采用彩色超声检查患者颈动脉IMT水平,对患者的空腹血糖水平、舒张压、收缩压、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、糖化血红蛋白、三酰甘油、总胆固醇等指标予以检测;采用Pearson法分析CA组患者颈动脉IMT与各临床指标的相关性;采用多元线性回归法分析T2DM患者颈动脉IMT的影响因素。结果CA组与对照组患者年龄、性别、糖尿病病程及DBP、HDL-C差异无统计学意义(P>0.05),相较于对照组患者,CA组患者SBP、BMI、TG、TC、LDL-C、HbA1c、FPG、FINS水平显著较高,差异有统计学意义(P<0.05)。相较于对照组患者,CA组患者血清sICAM-1、PRL、IMT水平显著较高,差异有统计学意义(P<0.05)。Pearson结果显示,患者IMT与BMI、SBP、TG、TC、LDL-C、HbA1c、FINS、sICAM-1、PRL呈正相关(P<0.05)。多元线性逐步回归分析结果显示,sICAM-1、PRL、LDL-C、TG、HbA1c是T2DM患者颈动脉IMT的影响因素(P<0.05)。结论T2DM合并动脉粥样硬化患者血清sICAM-1、PRL水平显著升高,颈动脉IMT显著增厚,且血清sICAM-1、PRL水平与颈动脉IMT呈正相关,临床中加强T2DM患者血清sICAM-1、PRL水平的监测,有助于及时对T2DM患者颈动脉病变过程进行监测及干预。Objective To detect the expression levels of serum intercellular adhesion factor-1(sICAM-1)and prolactin(PRL)in patients with type 2 diabetes mellitus,and to explore their correlation with carotid intima-media thickness(IMT).Methods From October 2018 to October 2019,112 patients with type 2 diabetes mellitus were selected for analysis and research.Among them,60 patients with carotid atherosclerosis were in the CA group,and 52 patients without carotid atherosclerosis were in the control group.The clinical data of two groups of patients were collected,and the serum sICAM-1 and PRL levels of the patients were detected by enzyme-linked immunosorbent assay(ELISA).Color ultrasonography was used to examine the carotid artery IMT level,and the fasting blood glucose level,diastolic blood pressure,systolic blood pressure,high-density lipoprotein cholesterol,low-density lipoprotein cholesterol,glycosylated hemoglobin,triacylglycerol,total cholesterol and other indicators were detected.Pearson's method was used to analyze the correlation between carotid artery IMT and various clinical indicators in CA group.Multiple linear regression was used to analyze the influencing factors of carotid IMT in T2DM patients.Results There were no statistically significant differences in age,gender,duration of diabetes,DBP and HDL-C between the CA group and the control group(P>0.05).Compared with the control group,the levels of SBP,BMI,TG,TC,LDL-C,HbA1c,FPG and FINS in the CA group were significantly higher,and the difference was statistically significant(P<0.05).Compared with the control group,the serum levels of sICAM-1,PRL and IMT in the CA group were significantly higher,and the difference was statistically significant(P<0.05).Pearson results showed that IMT was positively correlated with BMI,SBP,TG,TC,LDL-C,HbA1c,FINS,sICAM-1,and PRL(P<0.05).The results of multiple linear stepwise regression analysis showed that sICAM-1,PRL,LDL-C,TG and HbA1c were the influencing factors of carotid IMT in patients with T2DM(P<0.05).Conclusion Serum sICAM

关 键 词：2型糖尿病 可溶性细胞间粘附因子-1 泌乳素 颈动脉内膜中层厚度 

分 类 号：R587.1[医药卫生—内分泌]