小细胞外囊泡在牙周及牙髓再生中的应用与进展  

Application and progress of small extracellular vesicles in periodontal and pulp regeneration

作　　者：刘润园 董明[1] 韩文青 董炬宏 牛卫东[1] Liu Runyuan;Dong Ming;Han Wenqing;Dong Juhong;Niu Weidong(Department of Dentistry and Endodontics,School of Stomatology,Dalian Medical University,Dalian 116041,Liaoning Province,China)

机构地区：[1]大连医科大学口腔医学院牙体牙髓教研室,辽宁省大连市116041

出　　处：《中国组织工程研究》2023年第1期83-90,共8页Chinese Journal of Tissue Engineering Research

基　　金：辽宁省教育厅自然科学基础研究项目(LZ2019038),项目负责人:牛卫东;辽宁省教育厅面上项目(LJKZ0841),项目负责人:董明;辽宁省科学技术计划项目(2021JH2/10300027),项目负责人:牛卫东。

摘　　要：背景:小细胞外囊泡是细胞旁分泌途径中的重要成分,近些年小细胞外囊泡在口腔组织再生中的应用受到广泛关注。目的:对小细胞外囊泡在牙周和牙髓组织再生中的作用和应用进展做一综述。方法:检索近10年Pub Med、Web of science数据库及中国知网和万方医学数据库,英文检索词为“small extracellular vesicles,exosomes,pulp stem cells,periodontal regeneration,bone regeneration,pulp regeneration,regenerative endodontics,revascularization”,中文检索词为“小细胞外囊泡,外泌体,牙髓干细胞,牙周组织再生,骨再生,牙髓再生,牙髓血运重建”。经过文题、摘要的筛选,排除相关性差及陈旧和重复的文献,对最终符合标准的71篇文献进行综述。结果与结论:(1)小细胞外囊泡由多种细胞分泌,参与细胞间通讯,介导免疫应答反应,在组织再生中具有较大的应用潜力;(2)小细胞外囊泡在牙周组织修复再生中发挥重要的作用,可调控牙周炎症,促进牙周膜和周围骨组织再生;(3)小细胞外囊泡作用于牙源性干细胞可再生功能性牙髓-牙本质复合体。BACKGROUND:Small extracellular vesicles are important components of paracrine pathways.In recent years,the application of small extracellular vesicles in oral tissue regeneration attracted wide attention.OBJECTIVE:To review the role and application of small extracellular vesicles in periodontal and pulp tissue regeneration.METHODS:PubMed,Web of Science,CNKI and Wanfang databases were searched for relevant articles published in the past ten years.The retrieval MeSH Terms or key words were“small extracellular vesicles,exosomes,pulp stem cells,periodontal regeneration,bone regeneration,pulp regeneration,regenerative endodontics,revascularization”in Chinese and English,respectively.After removal of poorly related,outdated,and duplicate studies by reading the title and abstract,71 articles were finally included in result analysis.RESULTS AND CONCLUSION:(1)Small extracellular vesicles were secreted by many kinds of cells,participated in intercellular communication and mediated immune response.Small extracellular vesicles have a great application potential in tissue regeneration.(2)Small extracellular vesicles play an important role in periodontal tissue repair and regeneration.Small extracellular vesicles can regulate periodontal inflammation and promote periodontal ligament and surrounding bone tissue regeneration.(3)Small extracellular vesicles improve dental stem cells to regenerate functional pulp-dentin complexes.

关 键 词：小细胞外囊泡 外泌体 牙源性干细胞 牙周组织再生 骨再生 牙髓再生 牙髓血运重建 综述 

分 类 号：R459.9[医药卫生—治疗学] R318.08[医药卫生—临床医学]