酮酰胺化合物抗病毒活性及其天然产物来源  

Antiviral Activities of Ketoamide Compounds and the Natural Sources

作　　者：苏雨婷 李兆星 李娟 段彦 欧阳文 赵丽娟 张云坤 肖易倍 李顺祥 SU Yuting;LI Zhaoxing;LI Juan;DUAN Yan;OUYANG Wen;ZHAO Lijuan;ZHANG Yunkun;XIAO Yibei;LI Shunxiang(Hunan Province Engineering Research Center of Bioactive Substance Discovery of Chinese Medicine,School of Pharmacy,Hunan University of Chinese Medicine,Changsha 410208,China;School of Pharmacy,China Pharmaceutical University,Nanjing 211198,China)

机构地区：[1]湖南中医药大学药学院湖南省中药活性物质筛选工程技术研究中心,长沙410208 [2]中国药科大学药学院,南京211198

出　　处：《世界中医药》2022年第8期1171-1179,共9页World Chinese Medicine

基　　金：湖南省科学技术厅社会发展领域重点研发项目(2020SK3035)——2020年度创新型省份建设专项抗击新冠肺炎疫情专题项目;湖南中医药大学中药学一流学科项目(校行科字[2018]3号);长沙市科技计划项目(kh1902260)——蟾酥抗人乳头状瘤病毒的活性物质筛选及其医用产品的开发。

摘　　要：酮酰胺化合物对冠状病毒(CoV)、丙型肝炎病毒(HCV)、人类免疫缺陷病毒(HIV)、朊病毒(Pr)等病毒均表现出良好的抑制活性。本研究对酮酰胺化合物抗病毒活性及其天然产物来源进行综述,发现不少具有清热解毒功效的中药中含有此类成分,为酮酰胺化合物在防治CoV等病毒性疾病方面的开发应用提供参考。Ketoamide compounds show inhibitory activity against coronavirus(CoV),hepatitis C virus(HCV),human immunodeficiency virus(HIV),prion(Pr),and other viruses.This article reviews the antiviral activity of ketoamide compounds and the natural sources of them.It was found that many Chinese medicinals for clearing heat and detoxification contain such ingredients.The result can serve as a reference for the development and application of ketoamide compounds in the prevention and treatment of diseases caused by viruses such as CoV.

关 键 词：酮酰胺化合物 冠状病毒 丙型肝炎病毒 人类免疫缺陷病毒 朊病毒 抗病毒活性 天然产物 中药 

分 类 号：R285[医药卫生—中药学]