Methods in Determining the Bioequivalence of Inhaled Products  

作　　者：Sara M Tony Mohamed EA Abdelrahim 

机构地区：[1]Beni-Suef Specialized Hospital,Beni-Sueft Egypt [2]Clinical Pharmacy Department,Faculty of Pharmacy,Beni-Suef University Beni-Suef,Egypt

出　　处：《Journal of Clinical and Nursing Research》2022年第3期73-88,共16页临床护理研究（英文）

摘　　要：Aerosol delivery to the lungs can be achieved with several devices that differ in their operating mechanisms and efficacies of aerosol delivery.There are several methods to measure aerosol delivery and deposition in a subject's lung,in order to assess the efficacy of aerosol generators and the impact of certain drugs.Instruments such as cascade impactors,imaging techniques,and laser diffraction are available for measuring the particle size of aerosols,which is the main factor in the deposition and distribution of the produced aerosol.From impactors to laser difEractors,they have different operating mechanisms,analysis times,and characteristics,in which each has its own advantages and limitations.Several models are available to investigate aerosol delivery and deposition,such as in vitro,in vivo,and ex vivo models.

关 键 词：In vitro In vivo Ex vivo Clinical study 

分 类 号：X51[环境科学与工程—环境工程]