Th17 Cells and Tregs in HTLV-1 Infection  

作　　者：Nafiseh Saghafi Elham Abdollahi Malihe Hasanzadeh Mofrad 

机构地区：[1]Department of Gynecology and Obstetrics,Mashhad University of Medical Sciences,Mashhad,Iran [2]Immunology Research Center Inflammation and Inflammatory Disease Research Centre,Mashhad University of Medical Sciences,Mashhad,Iran

出　　处：《Journal of Clinical and Nursing Research》2022年第3期122-127,共6页临床护理研究（英文）

摘　　要：HTLV-1(human T-lymphotropic virus type 1)causes chronic infection ofhuman T lymphocytes.HTLV-1 infection is known to be related to multiple diseases,including neoplastic growth of HTLV-1-infected T cells(ATL)and neoplastic inflammatory conditions,such as HTLV-1-associated myelopathy/tropical spastic paraparesis(HAM/TSP),Sjogren's syndrome with arthritis,polymyositis uveitis,and bronchoalveolitis.Regulatory T cells(Tregs)regulate inflammatory cells,such as Th17 cells.The purpose of this study was to evaluate Tregs and Th17 cells,as well as the expression of related transcription factors(ROR-γ1 and FOXP3)and cytokines(IL-10,TGF-β,IL-6,and IL-17A)in HTLV-1 infection.

关 键 词：TREGS Th17 cells HTLV-1 HAMP/TSP 

分 类 号：R59[医药卫生—内科学]