新型2-吡啶酮衍生物的无催化剂合成  

Catalyst-free Synthesis of Novel 2-Pyridinone Derivatives

作　　者：张磊[1] 朱君 韩晓雪 张敏[1] 刘雄利[1] 邓国栋[1] ZHANG Lei;ZHU Jun;HAN Xiaoxue;ZHANG Min;LIU Xiongli;DENG Guodeng(National & Local Joint Engineering Research Center for the Exploitaion of Homology Resources of Medicine and Food, Guizhou University, Guiyang 550025, China)

机构地区：[1]贵州大学西南药食两用资源开发利用技术国家地方联合工程研究中心,贵州贵阳550025

出　　处：《合成化学》2022年第5期407-413,共7页Chinese Journal of Synthetic Chemistry

基　　金：贵大培育项目(202078)。

摘　　要：以3-烯基氧化吲哚/苯并呋喃酮-色酮合成子1为原料,在无催化剂作用下,与各种脂肪伯胺或者醋酸铵2发生开环和重新关环反应,获得了15个未见文献报道的新型2-吡啶酮衍生物3a~3o,产率为73%~93%,其结构经^(1)H NMR,^(13)C NMR和HR-MS(ESI-TOF)表征,通过单晶进一步确定了化合物3e的构型。该类化合物含有2-羟基苯甲酰基和2-吡啶酮生物活性骨架,在医药行业有一定应用价值。In this paper,3-vinyl oxindole/benzofuranone-chromone synthons 1 and various primary aliphatic amines or ammonium acetate 2 were used as raw materials,the ring opening and recyclization reaction occurred.Fifteen novel 2-pyridinone derivatives 3a~3o were obtained.The yields of 3a~3o were 73%~93%.The structures of products 3 were characterized by ^(1)H NMR,^(13)C NMR and HR-MS(ESI-TOF).The configuration of compound 3e was further determined by single crystals.These compounds contain two potential bioactive skeletons:2-hydroxy benzoyl group and 2-pyridinone,which have important potential value for the pharmaceutical industry.

关 键 词：双功能色酮合成子 胺 开环和重新关环反应 新型2-吡啶酮衍生物 合成 

分 类 号：O626.13[理学—有机化学] O623.7[理学—化学]