酶催化合成酰胺类化合物的研究进展  

Research Progress on Enzymatic Synthesis of Amides

作　　者：李正一 陈永正 万南微 LI Zhengyi;CHEN Yongzheng;WAN Nanwei(Green Pharmaceuticals Engineering Research Center of Guizhou Province, Key Laboratory of Biocatalysis & Chiral Drug Synthesis of Guizhou Province, School of Pharmacy, Zunyi Medical University, Zunyi 563000, China)

机构地区：[1]遵义医科大学药学院贵州省生物催化与手性药物合成重点实验室贵州省绿色制药工程研究中心,贵州遵义563000

出　　处：《合成化学》2022年第5期419-428,共10页Chinese Journal of Synthetic Chemistry

基　　金：国家自然科学基金资助项目(22167023)。

摘　　要：酰胺官能团具有重要的药理作用,是许多生物活性物质的关键结构单元。据报道,超过25%的已知药物中含有酰胺键结构。研究与发展酰胺类化合物的高效合成方法始终是制药行业的重要任务之一。近年来,生物催化技术的发展为酰胺键的构建提供了一种较为经济绿色的合成方法,丰富了酰胺类化合物的合成策略。本文综述了生物酶催化合成酰胺类化合物的相关研究进展。The amide group has important pharmacological activity and serves as the key structural unit of many biologically active compounds.It has been reported that more than 25%of the known drugs contain amide bond.Therefore,the research and development of efficient synthetic methods for amides have always been one of the important tasks in pharmaceutical industry.In recent years,the development of biocatalysis technology has provided a more economical and green synthetic methods for the construction of amides,enriching the synthesis strategies for amides.This article reviews the research progress of enzymatic methodologies for the synthesis of amides.

关 键 词：生物催化 酰胺 绿色合成 制药技术 生物酶 研究进展 

分 类 号：O622.6[理学—有机化学]