2175例新发现HIV感染者治疗前CD4^(+)T细胞计数分析  

Analysis of the CD4^(+)T cell count test of the 2175 newly untreated reported HIV infected person

作　　者：张之[1] 邱涛[1] 孙承青 史灵恩[1] 周莹[1] 卢静[1] 胡海洋[1] 傅更锋[1] 徐晓琴[1] Zhang Zhi;Qiu Tao;Sun Chengqing;Shi Ling′en;Zhou Ying;Lu Jing;Hu Haiyang;Fu Gengfeng;Xu Xiaoqin(Dept of HIV/STD Control and Prevention,Jiangsu Provincial Center for Disease Control and Prevention,Nanjing 210009;School of Public Health, Nanjing Medical University, Nanjing 211166)

机构地区：[1]江苏省疾病预防控制中心性病与艾滋病防制所,南京210009 [2]南京医科大学公共卫生学院,南京211166

出　　处：《安徽医科大学学报》2022年第5期827-831,共5页Acta Universitatis Medicinalis Anhui

基　　金：国家科技重大专项(民口)课题(编号:2018ZX10715-002);江苏省卫生健康委科研课题(编号:Z2018039)。

摘　　要：目的分析江苏省新发现HIV感染者CD4^(+)T淋巴细胞计数水平,了解其免疫状态和疾病进程,为全省艾滋病防控策略提供科学依据。方法使用流式细胞仪对2020年新确证且尚未治疗的HIV感染者进行CD4^(+)T细胞绝对计数检测,利用多因素Logistic回归分析影响CD4^(+)T细胞计数结果的因素。结果2020年江苏省新发现HIV感染者2175例,其中<30岁、同性传播、未婚、大专及以上学历、学生、检测咨询和流动人口CD4^(+)T细胞绝对计数水平较高(P<0.05);多因素Logistic回归分析结果显示,年龄≥30岁、医疗机构确诊人群更容易出现晚发现情况(P<0.05)。结论江苏省近几年对男男性行为人群(MSM)的干预策略效果明显,今后应对≥30岁、已婚或离异、异性传播、高中及以下学历、农民或民工或离退人员及医疗机构就诊人群加强关注,推进全省医务人员主动提供艾滋病检测咨询(PITC)服务,加大宣传、干预力度,尽早检测。Objective To analyze the CD4^(+)T cell count level of newly diagnosed HIV infected patients in Jiangsu province,and to understand their immune status and disease progression so as to provide scientific basis for HIV prevention and control strategy in the whole province.Methods Flow cytometry was used to detect the absolute count of CD4^(+)T lymphocytes in newly diagnosed patients who had not initiated ART in 2020.Multivariate Logistic regression was used to analyze the associated factors of CD4^(+)T cell count.Results In 2020,there were 2175 new diagnosed cases with HIV infection in Jiangsu Province.Patients under 30 years old,infected by homosexual transmission,unmarried,with college degree or above,students,diagnosed in counseling and testing and floating population had a higher absolute count level of CD4^(+)T cell count(P<0.05).Multivariate Logistic regression analysis showed that people aged≥30 and diagnosed in medical institutions were more likely to be presented lately(P<0.05).Conclusion In recent years,the intervention strategy for men who had sex with men(MSM)in Jiangsu province had achieved remarkable results.In the future,much more attention should be paid for the population over or equal to 30 years old,married or divorced,infected by heterosexual transmission,with high school education or below,farmers or migrant workers,retirees and diagnosed in medical institutions so that the PITC service should be promoted,and the publicity and intervention should be strengthened to present cases as soon as possible.

关 键 词：CD4^(+)T淋巴细胞 人类免疫缺陷病毒 晚发现 

分 类 号：R183.9[医药卫生—流行病学]