中医鼻病序贯疗法治疗变应性鼻炎肺虚感寒证临床研究  

Clinical study on Sun's sequential therapy of allergic rhinitis with lung deficiency and cold syndrome

作　　者：陈嘉楠 孙书臣[2] 杨丽[2] Chen Jianan;Sun Shuchen;Yang Li(Master Degree Student of Grade 2020,Beijing University of Chinese Medicine,Beijing 100029,China;Ear-Nose-Throat Department,Guang'anmen Hospital,China Academy of Chinese Medical Sciences,Beijing 100053,China)

机构地区：[1]北京中医药大学,北京100029 [2]中国中医科学院广安门医院耳鼻喉科,北京100053

出　　处：《国际中医中药杂志》2022年第4期380-383,共4页International Journal of Traditional Chinese Medicine

基　　金：中国中医科学院科技创新工程重大攻关项目耳鼻咽喉科学(CI2021A02702);北京市大兴区孙书臣名医工作室项目(BJDX-MYGZS-2021-2023)。

摘　　要：目的评价中医鼻病序贯疗法治疗变应性鼻炎(allergic rhinitis,AR)肺虚感寒证的疗效。方法将符合入选标准的2020年1-7月广安门医院耳鼻喉科门诊AR肺虚感寒证患者60例,按随机数字表法分为2组,每组30例。中药口服组仅口服玉屏风散合苍耳子散加味,序贯疗法组口服结合熏蒸玉屏风散合苍耳子散加味。2组均连续治疗14 d。分别于治疗前后进行临床症状评分,采用Sheldon法进行鼻黏膜嗜酸性粒细胞(EOS)分级,评价临床疗效。结果序贯疗法组25例、中药口服组28例进入疗效统计。序贯疗法组总有效率为88.0%(22/25)、中药口服组为89.3%(25/28),2组比较差异无统计学意义(χ^(2)=2.83,P=0.883)。序贯疗法组治疗后鼻塞、流涕、喷嚏评分及总分低于中药口服组(P<0.01),鼻黏膜EOS分级差值[(2.76±0.27)级比(1.52±0.36)级]高于中药口服组(P=0.01)。结论中医鼻病序贯疗法可有效改善AR肺虚感寒证患者鼻塞、流涕、喷嚏症状,减少鼻黏膜EOS分布,临床疗效与口服中药相近,且安全性较好。Objective To evaluate the efficacy of Sun's sequential therapy(SST)of Chinese Medicine on allergic rhinitis with lung deficiency and cold syndrome.Methods A total of 60 AR patients with lung deficiency and cold syndrome in otolaryngology clinic of Guang'anmen Hospital,from January to July 2020,who met the inclusion criteria,were randomly divided into 2 groups according to the random number table method,with 30 patients in each group.The Traditional Chinese Medicine(TCM)group was treated with oral Yupingfeng Powder and Cang'erzi Powder and the SST group was treated with oral and nasal steaming of Yupingfeng Powder and Cang'erzi Powder.Both groups were treated for 14 days.The clinical symptoms were scored before and after treatment,and the Nasal mucosa eosinophil(EOS)count was graded by Sheldon method to evaluate the clinical efficacy.Results Twenty five patients in the SST group and 28 in the TCM group were analyzed.The total effective rate was 88.0%(22/25)in the SST group and 89.3%(25/28)in the TCM group,and there was no significant difference between the two groups(χ^(2)=2.83,P=0.883).The scores of nasal obstruction,runny nose,sneeze and total score in the SST group were significantly lower than those in the TCM group(P<0.01),and the difference of Nasal mucosa EOS grade in SST group(2.76±0.27 vs.1.52±0.36)was significantly higher than that of the TCM group(P=0.01).Conclusion The SST of Chinese medicine can improve the symptoms of nasal congestion,runny nose and sneezing in AR patients with lung deficiency and cold syndrome,and reduce the distribution of Nasal mucosa EOS.

关 键 词：鼻炎 变应性 序贯疗法 玉屏风散 苍耳子散 

分 类 号：R276.1[医药卫生—中医五官科学]