淫羊藿性激素样作用研究进展  

Research progress on sex-hormone-like effects of epimedium

作　　者：王海征[1] 张琪 陈雯[3] 杨响光[3] 陈菲[1] 庄伟[1] 朱丽[3] Wang Haizheng;Zhang Qi;Chen Wen;Yang Xiangguang;Chen Fei;Zhuang Wei;Zhu Li(Department of Pharmacy,Xuanwu Hospital,Capital Medical University,Beijing 100053,China;Magazine Publishing Center,Institute of Information on Traditional Chinese Medicine,China Academy of Chinese Medical Sciences,Beijing 100700,China;Department of Pharmacy,Guang'anmen Hospital,China Academy of Chinese Medical Sciences,Beijing 100053,China)

机构地区：[1]首都医科大学宣武医院药学部,北京100053 [2]中国中医科学院中医药信息研究所杂志出版中心,北京100700 [3]中国中医科学院广安门医院药剂科,北京100053

出　　处：《国际中医中药杂志》2022年第4期465-468,共4页International Journal of Traditional Chinese Medicine

基　　金：国家中医管理局全国中医药创新骨干人才培训项目(国中医药人教函〔2019〕128号);北京市中医管理局北京市第二批中药骨干人才培养项目(京中医科字〔2018〕213号)。

摘　　要：淫羊藿是常用的温肾壮阳药,具有雄、雌性激素样作用,不仅可直接作用于性器官调节激素水平,还可通过下丘脑-垂体-性腺轴发挥性激素样作用,其对激素水平的调节与植物激素特点相似。目前临床常用淫羊藿与其他中药配伍治疗性激素缺乏相关疾病,如男性精子减少症、弱精子症、前列腺增生、功能性勃起功能障碍,以及女性卵巢早衰、围绝经期综合征、排卵期障碍性不孕症、PCOS患者高雄激素血症等,临床疗效较好。Epimedii folium is a commonly used Traditional Chinese Medicine(TCM)for warming the kidney and strengthening the yang qi.It has androgen-estrogen-like effect.It can not only directly act on sexual organs to regulate hormone levels,but also exert sex-hormone-like effect through hypothalamus-pituitary-gonadal axis.Its regulation of hormone levels is similar to that of plant hormones.At present,Epimedii folium is commonly used with other TCMs to treat diseases caused by sex-hormone deficiency,such as male spermatopenia,asthenospermia,benign prostatic hyperplasia,functional erectile dysfunction,female premature ovarian failure,perimenopausal syndrome,dysfunctional infertility during ovulation,hyperandrogenemia of PCOS patients,etc.

关 键 词：淫羊藿 雌激素样作用 雄激素样作用 下丘脑-垂体-性腺轴 基础研究 临床研究 综述 

分 类 号：R285[医药卫生—中药学]