针灸效应与线粒体动力学  

Acupuncture effects and mitochondrial dynamics

作　　者：吴长乐 张利 袁懿芸 李永丰 吴宇蔚 哈略 杨海永 邢文文[2] 乔海法 杨晓航 刘奇 WU Chang-le;ZHANG Li;YUAN Yi-yun;LI Yong-feng;WU Yu-wei;HA Lue;YANG Hai-yong;XING Wen-wen;QIAO Hai-fa;YANG Xiao-hang;LIU Qi(College of Acupuncture-Moxibustion and Tuina,Shaanxi University of Chinese Medicine,Xi'an 712046,China;College of Basic Medicine,Shaanxi University of Chinese Medicine,Xi'an 712046,China;College of Medical Technology,Shaanxi University of Chinese Medicine,Xi'an 712046,China)

机构地区：[1]陕西中医药大学针灸推拿学院,西安712046 [2]陕西中医药大学基础医学院,西安712046 [3]陕西中医药大学医学技术学院,西安712046

出　　处：《中华中医药杂志》2022年第4期2152-2156,共5页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：国家自然科学基金项目(No.82074567,No.81704186);陕西省自然科学基础研究计划(No.2017JQ8020);陕西中医药大学学科创新团队(No.2019-YL09)。

摘　　要：线粒体不断进行分裂与融合的动态平衡过程称为线粒体动力学,这一过程能维持自身形态、分布、数量和功能,是细胞进行各种生理活动的重要前提。线粒体动力学失衡,线粒体结构和功能会发生异常,进而参与多种疾病的发生发展。文章通过研究线粒体动力学的生理病理过程、调控因子、影响因素以及针灸对线粒体动力学的调控效应和可能机制,结果发现,针灸基于多靶点、多层次,可以影响线粒体分裂蛋白和(或)融合蛋白的表达,对线粒体动力学产生调控效应,从而发挥双向良性调节效能,综合改善线粒体动力学的失衡状态,并最终影响能量代谢,实现对阿尔茨海默病等相关疾病的防治作用。The dynamic equilibrium process of continuous mitochondrial division and fusion is known as mitochondrial dynamics,a process that maintains its own morphology,distribution,quantity and function,and is an important prerequisite for cells to carry out a variety of physiological activities.When mitochondrial dynamics are out of balance,mitochondrial structure and function will be abnormal,which in turn is involved in the development of many diseases.This paper investigates the physiological and pathological processes,regulatory factors and influencing factors of mitochondrial dynamics,as well as the regulatory effects and possible mechanisms of acupuncture on mitochondrial dynamics.The results show that acupuncture can influence the expression of mitochondrial fission proteins and/or fusion proteins based on multiple targets and levels,and exert a regulatory effect on mitochondrial dynamics,thus exerting a two-way benign regulatory effect and comprehensively improving the imbalance of mitochondrial dynamics,and ultimately affecting energy metabolism to achieve the prevention and treatment of Alzheimer’s disease and other related diseases.

关 键 词：线粒体 线粒体动力学 针灸 综述 

分 类 号：R245[医药卫生—针灸推拿学]