重复经颅磁刺激作用的脑机制研究进展  

Progress on Brain Mechanisms of Repetitive Transcranial Magnetic Stimulation

作　　者：樊衍孜 吕亚婷 FAN Yanzi;LYU Yating(Center for Cognition and Brain Disorders,The Affiliated Hospital of Hangzhou Normal University,Hangzhou 310015,China;Institutes of Psychological Sciences,Hangzhou Normal University,Hangzhou 311121,China;Zhejiang Key Laboratory for Research in Assessment of Cognitive Impairments,Hangzhou 311121,China)

机构地区：[1]杭州师范大学附属医院认知与脑疾病研究中心,浙江杭州310015 [2]杭州师范大学心理科学研究院,浙江杭州311121 [3]浙江省认知障碍评估重点实验室,浙江杭州311121

出　　处：《杭州师范大学学报（自然科学版）》2022年第3期254-260,共7页Journal of Hangzhou Normal University(Natural Science Edition)

基　　金：科技部国家重点研发计划项目(2017YFC1310000);国家自然科学基金项目(81771911);浙江省基础公益研究计划项目(LGJ22H180001);杭州师范大学省优势特色学科培育项目(20JYXK026).

摘　　要：重复经颅磁刺激(repetitive transcranial magnetic stimulation,rTMS)不仅可以在刺激时产生兴奋或抑制皮层兴奋性的作用,其效果还可以持续到刺激停止后的一段时间,从而发挥神经调控作用,为rTMS应用于临床治疗提供可能.近些年,多种神经影像技术已被用于探究rTMS引起的脑机制的变化.文章概述了目前已有的基于多种脑成像技术手段研究rTMS刺激健康人初级运动区所引起大脑活动变化的文献,了解rTMS作用的脑机制,并总结现有研究的不足,展望未来的研究方向,以期为rTMS治疗运动障碍提供参考.Repetitive transcranial magnetic stimulation(rTMS)could induce excitatory or inhibitory effects on cortical excitability during stimulation.Furthermore,its long-lasting neuromodulation beyond the stimulation period could make rTMS suitable for the treatment of neurological and psychiatric disorders.In recent years,a variety of neuroimaging techniques have been served as promising tools to explore neural mechanism underlying rTMS intervention.This paper provides an overview of recent studies,which investigates the alterations of brain activity using neuroimaging techniques after the application of rTMS over the primary motor cortex in healthy controls,understands the brain mechanism of rTMS,and discusses the future perspectives and considerations of its application.This review may provide the guidance for rTMS used as a therapeutic tool in dyskinesia.

关 键 词：重复经颅磁刺激 脑成像 初级运动皮层 

分 类 号：Q189[生物学—神经生物学]