Complex Drug Network of Danshen Chuanxiongqin Injection(丹参川芎嗪注射液)Treatment for Liver Insufficiency  

作　　者：DONG Han-shuo ZHANG Li-dan XIE Yan-ming YANG Yun-yun 董晗硕;张利丹;谢雁鸣;杨云云(Institute of Basic Research in Clinical Medicine,China Academy of Chinese Medical Sciences,Beijing 100700,China;Jilin Academy of Chinese Medicine Sciences,Changchun 130000,China;Renmin University of China,Beijing 100872,China)

机构地区：[1]Institute of Basic Research in Clinical Medicine,China Academy of Chinese Medical Sciences,Beijing 100700,China [2]Jilin Academy of Chinese Medicine Sciences,Changchun 130000,China [3]Renmin University of China,Beijing 100872,China

出　　处：《World Journal of Integrated Traditional and Western Medicine》2022年第2期1-11,共11页世界中西医结合杂志（英文）

基　　金：Science and Technology Innovation Project of Chinese Academy of Traditional Chinese Medicine(Project No.CI2021A00702);National Key R&D Program"Evidence-based Evaluation of Ten Major Varieties of Chinese Medicines and Classical Formulas for the Treatment of Major Diseases and Demonstration of Their Effect Mechanisms after Marketing"(2018YFC1707400)。

摘　　要：Objective:To study the characteristics and rules of medication regimen for patients with Liver insufficiency treated with Danshen Chuanxiongqin Injection.Methods:The inpatient information of Danshen Chuanxiongqin Injection with Liver insufficiency was extracted from the hospital information system(HIS)database of 12 Class A tertiary hospitals in China.Tabu search(TS)algorithm was used for obtaining sub-network and density matrix,matrix method or sociogram was used to show the relationship between different sub-networks,searching for core prescriptions of treatment options,associations and strong correlations between multiple drugs.Results:The treatment plan of integrated Chinese and Western medicine of Danshen Chuanxiongqin Injection on Liver insufficiency mainly includes of cerebrovascular disease in acute stress state:Danshen Chuanxiongqin Injection combined with alanyl glutamine;Treatment of acute ischemic cardiovascular and cerebrovascular diseases:Danshen Chuanxiongqin Injection combined with Levocarnitine+acetylsalicylic acid+inosine tablets+brain protein hydrolysate+glutathione+furosemide+Magnesium aspartate+metoprolol;Treatment of ischemic cardiomyopathy angina pectoris with traditional Chinese medicine:Danshen Chuanxiongqin Injection combined with Shexiang Baoxin Pills+Suxiao Jiuxin Pills+Fufang Danshen Drops;Treatment of ischemic cardiovascular disease complicated with Liver insufficiency with traditional Chinese medicine:Danshen Chuanxiongqin Injection combined with Dazhu Hongjingtian Capsule+Shuganning Injection.Conclusion:For Danshen Chuanxiongqin Injection in patients with Liver insufficiency,on the basis of conventional symptomatic treatment,attention should be paid to the liver function of the patients,integrated therapy can be more selective,can improve the efficacy in different degrees.Danshen Chuanxiongqin Injection combination scheme of Liver insufficiency in routine clinical diagnosis and treatment provides a more effective reference for clinical individualized treatment.

关 键 词：Danshen Chuanxiongqin Complex drug network Liver insufficiency 

分 类 号：R259[医药卫生—中西医结合]