HTK液与Del Nido液对心脏手术中心肌保护作用的Meta分析  

The protective effect of HTK solution and Del Nido solution on myocardium during cardiac surgery:Meta-analysis

作　　者：尹芳芳 王萌 李玉明 胡金朋 鞠东玲 YIN Fang-fang;WANG Meng;LI Yu-ming;HU Jin-peng;JU Dong-ling(Department of Thoracic Cardiovascular Surgery,Special Medical Center of Armed Police Force,Tianjin 300162,China;不详)

机构地区：[1]武警特色医学中心胸心血管外科,天津300162 [2]武警特色医学中心研究部,天津300162 [3]武警特色医学中心军人全科医学科,天津300162

出　　处：《中国临床研究》2022年第5期599-605,共7页Chinese Journal of Clinical Research

基　　金：国家重点研发项目(2017YFC1307602);武警部队面上项目(CWJ18L004)。

摘　　要：目的系统评价HTK液与Del Nido液在心脏手术中的心肌保护作用。方法通过计算机系统检索The Cochrane Library、PubMed、Embase、万方、CBM、CNKI、维普数据库中直接比较HTK液(HTK组)与Del Nido液(DN组)对心脏手术中心肌保护作用的相关文献,并经RevMan 5.3软件进行数据合并分析。结果共纳入8篇符合条件的相关文献,HTK组的停搏液使用总量显著高于DN组(MD=147.92,95%CI:62.52~233.32,P<0.01),而DN组的输血量显著高于HTK组(MD=-33.07,95%CI:-58.89~-6.25,P=0.02),但两组的体外循环时间、主动脉阻断时间、术后机械通气时间、ICU入住时间、总住院时间、术后左心室射血分数、房颤发生率及术后24 h的心肌酶谱水平差异均无统计学意义(P>0.05)。结论在心脏手术患者中,HTK与DN对心肌的保护作用相当,具有相似的临床疗效。Objective To systematically evaluate the myocardial protective effect of HTK solution and Del Nido solution in cardiac surgery.Methods The relevant literatures on the direct comparison of HTK solution(HTK group)and Del Nido solution(DN group)on myocardial protection in cardiac surgery were searched in the database of the Cochrane Library,PubMed,Embase,Wanfang,CBM,CNKI,and VIP through a computer,and data was merged and analyzed by RevMan 5.3 software.Results A total of 8 relevant studies were included.The total amount of cardioplegia in the HTK group was significantly higher than that in the DN group(MD=147.92,95%CI:62.52-233.32,P<0.01),while the amount of blood transfusion in the DN group was significantly higher than that in the HTK group(MD=-33.07,95%CI:-58.89--6.25,P=0.02).However,there was not significantly different in the cardiopulmonary bypass time,aortic occlusion time,postoperative mechanical ventilation time,ICU stay time,total hospital stay time,postoperative left ventricular ejection fraction,incidence of atrial fibrillation,and myocardial enzyme spectrum levels at 24 h after operation between the two groups(P>0.05).Conclusion In cardiac surgery patients,HTK and DN have equivalent protective effects on myocardium and have similar clinical effects.

关 键 词：体外循环 组氨酸-色氨酸-酮戊二酸溶液 Del Nido停搏液 心脏手术 

分 类 号：R654.2[医药卫生—外科学]