双膦酸盐抗骨吸收治疗中对糖代谢的可能影响  

Possible effect of Bisphosphonate on glucose metabolism in anti-bone resorption therapy

作　　者：姚瑶[1] 朱亦堃[2] YAO Yao;ZHU Yi-kun(Department of Endocrinology,The Second Clinical College of Shanxi Medical University,Taiyuan,Shanxi 030001,China;不详)

机构地区：[1]山西医科大学第二临床医学院内分泌科,山西太原030001 [2]山西医科大学第二医院内分泌科,山西太原030001

出　　处：《中国临床研究》2022年第5期708-712,共5页Chinese Journal of Clinical Research

基　　金：山西省卫生健康委员会科研基金资助项目(2020067);山西省回国留学人员科研资助项目(2017-121)。

摘　　要：双膦酸盐类药物(BPs)是治疗骨质疏松症及糖尿病性骨质疏松的一线和最具成本效益的药物。但至今各研究数据表明,BPs对糖代谢(糖尿病风险和胰岛素敏感性)的影响尚不明确。本文将对其研究进展作一综述,为BPs治疗糖尿病合并骨质疏松症提供参考依据。Bisphosphonates(BPs)are the first-line and cost-effective drugs for the treatment of osteoporosis and diabetes-induced osteoporosis.However,data from various studies have shown that the effects of BPs on glucose metabolism(diabetes risk and insulin sensitivity)are unclear.This article reviews its research progress and further provide evidence for BPs in the treatment of diabetes mellitus combined with osteoporosis.

关 键 词：双膦酸盐 糖尿病 骨钙素 骨质疏松 糖代谢 维生素D 

分 类 号：R58[医药卫生—内分泌]