两种5-单取代丙二酸亚异丙酯衍生物的合成  

A Study on Synthesis of Two 5-monosubstitution Isopropylidene Malonate

作　　者：韩小见[1] Han Xiao-jian(Department of Chemistry Changzhi University,Changzhi Shanxi 046011)

机构地区：[1]长治学院化学系,山西长治046011

出　　处：《长治学院学报》2022年第2期37-40,共4页Journal of Changzhi University

基　　金：长治学院科研项目(XJ2020000602)。

摘　　要：文章以丙酮和丙二酸为原料,在乙酸酐和浓硫酸作用下合成丙二酸亚异丙酯,再用固相合成法和芳醛经Knoevenagel缩合制备芳亚甲基丙二酸亚异丙酯,随后用硼氢化钠还原,经三步合成两种5-单取代丙二酸亚异丙酯(3a和3b),总产率分别为22.5%和18.6%。本方法具有条件温和、操作简单和产率较高的特点,为丙二酸亚异丙酯衍生物的合成提供了新的研究思路。In this paper,two kinds of 5-mono replaced isopropylidene malonate through 3 steps with total yield of 22.5%and 18.6%respectively.Briefly,isopropylidene malonate was firstly synthesized by acetone and propylene acid in the presence of acetic anhydride and concentrated sulfuric acid,which was then reacted with aromatic aldehydes by solid phase synthesis to provide arymethyiene isopropylidene malonate through the mechanism of Knoevenagel condensation.The desired target products are obtained after reduction under the condition of sodium borohydride.The advantages of this procedure include mild conditions,simple operation and high production rate,which will shed light on the synthesis of malonic acid isopropyl ester derivatives.

关 键 词：丙二酸亚异丙酯 KNOEVENAGEL缩合 固相合成 

分 类 号：O62[理学—有机化学]