河南省农村地区HIV/AIDS患者生存质量及影响因素研究  

Quality of Life and Influencing Factors in Henan Rural People Living with HIV/AIDS

作　　者：杨俊 李鹏宇[2] 金艳涛[2] 裴金燕 臧静愉 刘亚楠[1] 贾皇超 吴智慧 张振奎 王月园 郭会军[2] YANG Jun;LI Pengyu;JINYantao;PEI Jinyan;ZANG Jingyu;LIU Yanan;JIA Huangchao;WU Zhihui;ZHANG Zhenkui;WANG Yueyuan;GUO Huijun(Henan University of Chinese Medicine,Zhengzhou 450046,China;AIDS Clinical Research Center,the First Affiliated Hospital of Henan University of CM,Zhengzhou 450003,China)

机构地区：[1]河南中医药大学,河南省郑州市450046 [2]河南中医药大学第一附属医院艾滋病临床研究中心,河南省郑州市450003

出　　处：《中国全科医学》2022年第21期2646-2650,共5页Chinese General Practice

基　　金：国家“十三五”传染病防治科技重大专项课题(2017ZX10205502002);国家自然科学基金资助项目(81873187);河南省中医药科学研究专项重大课题(20-21ZYZD03)。

摘　　要：背景人免疫缺陷病毒感染/艾滋病(HIV/AIDS)是一种严重危害公众健康的公共卫生事件,随着针对HIV/AIDS患者社会支持政策的实施,患者的病死率明显下降,但是其目前的生存现状仍备受关注。目的分析河南农村地区HIV/AIDS患者的生存质量及其影响因素。方法于2020-06-03至2020-06-12采用整群抽样方法选取河南某地区疾病预防控制中心在册管理的且正在接受高效抗反转录病毒治疗(HAART)的HIV/AIDS患者,收集患者的一般资料及实验室检查结果,采用世界卫生组织艾滋病生存质量简表(WHOQOL-HIV BREF)中文版对患者的生存质量进行评估。采用多重线性回归分析探讨HIV/AIDS患者生存质量的影响因素。结果发放调查表415份,回收合格调查表400份,调查表合格率为96.39%。400例HIV/AIDS患者均为汉族,其中男性、50岁以上、有配偶、无稳定收入者居多,文化水平偏低,以血液传播感染为主,多数患者确诊时间>8年、HAART持续时间>8年、CD;T淋巴细胞计数>500个/μl。不同性别、年龄、文化程度、婚姻状况、收入方式、感染途径、确诊时间及HAART持续时间患者的WHOQOL-HIV BREF总分比较,差异均有统计学意义(P<0.05)。多重线性回归分析结果显示,年龄(β’=-0.152)、婚姻状况(β’=0.171)、收入方式(β’=-0.138)、感染途径(β’=0.104)是HIV/AIDS患者生存质量的影响因素(P<0.05)。结论对于年龄>50岁、无配偶、无稳定收入、经血液传播的HIV/AIDS患者的生活质量应重点关注。Background HIV/AIDS is an issue that seriously endangers public health.With the implementation of social support policies for people living with HIV/AIDS,although the mortality of them has decreased significantly,their survival is still a big concern.Objective To understand the quality of life and influencing factors in people living with HIV/AIDS in Henan rural areas.Methods By use of cluster sampling,we selected the persons living with HIV/AIDS treated by highly active antiretroviral therapy(HAART)who were managed by the local center for disease control and prevention in a rural area of Henan from June 3 to June 12,2020.We collected their general data and laboratory test findings,and assessed their quality of life using the Chinese version of the WHOQOL-HIV BREF.We used multiple linear regression to identify the associated factors of quality of life.Results A total of 415 cases attended the questionnaire survey,and 400 of them(96.39%)who effectively completed the questionnaire were finally included for analysis.All the respondents were Han people,most of them were diagnosed over eight years,males,and aged over 50 years,and had a spouse,no stable income,low education level and CD;T lymphocytes greater than 500/μl with transmission mainly through blood,and over eight years of continuous HAART.The total score of quality of life of the respondents differed by sex,age,education level,marital status,income status,route of getting HIV infection,time of HIV diagnosis,and continuous treatment duration of HAART(P<0.05).Multiple linear regression analysis indicated that age(β’=-0.152),marital status(β’=0.171),income status(β’=-0.138),and route of getting HIV infection(β’=0.104)were associated with the quality of life(P<0.05).Conclusion Special attention should be given to the quality of life of people living with HIV/AIDS infected by blood contact with an age of over 50 years,no spouse,and no stable income.

关 键 词：获得性免疫缺陷综合征 HIV 抗逆转录病毒治疗 高效 生存质量 影响因素分析 

分 类 号：R512.91[医药卫生—内科学]