基于交替方向乘子法(ADMM)直接重建心脏^(11)C-acetate PET动力学参数图  

Direct reconstruction of cardiac^(11)C-acetate PET kinetic parametric images based on alternating direction method of multipliers(ADMM)

作　　者：何升级 刘帅 张辉[2] 霍力[3] 尚斐[1] HE Shengji;LIU Shuai;ZHANG Hui;HUO Li;SHANG Fei(Department of Biomedical Engineering,School of Life Science,Beijing Institute of Technology,Beijing 100081,China;Department of Biomedical Engineering,School of Medicine,Tsinghua University,Beijing 100084,China;Department of Nuclear Medicine,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences&Peking Union Medical College,Beijing 100730,China)

机构地区：[1]北京理工大学生命学院生物医学工程系,北京100081 [2]清华大学医学院生物医学工程系,北京100084 [3]中国医学科学院北京协和医学院北京协和医院核医学科,北京100730

出　　处：《中国医学影像技术》2022年第5期758-763,共6页Chinese Journal of Medical Imaging Technology

摘　　要：目的观察基于交替方向乘子法(ADMM)直接重建心脏^(11)C-acetate PET动力学参数图的价值。方法基于1例早期酒精性心肌病患者的心脏^(11)C-acetate PET图像构建理想动态图像,通过投影生成正弦图,加入泊松噪声,并将PET图像重建与基于心脏^(11)C-acetate单室模型动力学参数计算结合,采用ADMM直接重建心脏^(11)C-acetate PET动力学参数图;基于有序子集最大期望值法(OSEM)间接重建心脏参数图。观察两种重建方法与参考标准的相关性,评估直接重建法的价值。结果间接重建法耗时23 min,直接重建法耗时140 min。参考标准与通过间接重建得到的K_(1)、k_(2)和vl值的平均偏差分别为2.97%、1.61%和10.19%,与通过直接重建得到的K_(1)、k_(2)和vl值的平均偏差分别为1.16%、1.06%和4.30%。参考标准与通过间接重建或直接重建得到的K_(1)、k_(2)和vl均呈高度相关(r均>0.9,P均<0.001)。结论相比间接重建法,基于ADMM直接重建心脏^(11)C-acetate PET动力学参数图的准确性更高。Objective To observe the value of direct reconstruction of cardiac ^(11)C-acetate PET kinetic parametric images based on alternating direction method of multipliers(ADMM).Methods Data of ^(11)C-acetate PET images of 1 patient with early alcoholic cardiomyopathy was used to generate the ideal dynamic images,and the images were then projected to generate sinograms and added Poisson noise.PET images reconstruction were combined with the parameters calculation based on cardiac ^(11)C-acetate single tissue compartment model,and the cardiac ^(11)C-acetate PET kinetic parametric images were directly reconstructed with ADMM.The parametric images were indirectly reconstructed with ordered subsets expectation maximization(OSEM).The correlations of two reconstruction methods and reference standard were observed,and the value of direct reconstruction method was analyzed.Results The indirect reconstruction took_(2)3 min,while the direct reconstruction took 140 min.The average biases of K_(1),k_(2)and vl calculated with reference standard and indirect reconstruction was 2.97%,1.61%and 10.19%,respectively,while between reference standard and direct reconstruction was 1.16%,1.06%and 4.30%,respectively.K_(1),k_(2)and vl calculated with indirect or direct reconstruction were all strongly correlated with reference standard(all r>0.9,all P<0.001).Conclusion Compared with indirect reconstruction,the accuracy of direct reconstruction of cardiac ^(11)C-acetate PET kinetic parametric images based on ADMM was higher.

关 键 词：心脏 非线性动力学 正电子发射断层显像 示踪剂 交替方向乘子法 

分 类 号：R542.2[医药卫生—心血管疾病] R817.4[医药卫生—内科学]