星形胶质细胞在创伤性颅脑损伤中的研究进展  

Review on research progress of astrocytes in traumatic brain injury

作　　者：史文哲 罗文哲[1] 王星凯 郭梦凡[2] 尹兴忠[1] 盛延良[1] SHI Wen-zhe;LUO Wen-zhe;WANG Xing-kai;GUO Meng-fan;YIN Xing-zhong;SHANG Yan-liang(School of Basic Medicine,Jiamusi University,Key Laboratory of Microecology-immune Regulatory Network and Related Diseases Jiamusi,Heilongjiang 154000;Department of Pathology,the first affiliated Hospital of Jiamusi University,Jiamusi,Heilongjiang 154007,China)

机构地区：[1]佳木斯大学基础医学院,黑龙江省微生态-免疫调节网络与相关疾病重点实验室,黑龙江佳木斯154000 [2]佳木斯大学附属第一医院病理科,黑龙江佳木斯154007

出　　处：《医药论坛杂志》2022年第7期108-112,共5页Journal of Medical Forum

摘　　要：星形胶质细胞是中枢神经系统的主要稳态细胞,其对正常的神经元发育、功能、代谢及对损伤和炎症的反应至关重要,在中枢神经系统的生理和病理过程中发挥着不可或缺的作用。近期研究发现,星形胶质细胞在颅脑损伤后至少活化为两种不同的反应性星形胶质细胞,即A1型(神经毒性)和A2型(神经保护性)。不同分型的星形胶质细胞在颅脑损伤后不同时间点表达并发挥不同作用。文章重点从反应性星形胶质细胞的分型、作用、颅脑损伤后表达时间及机制等方面予以综述。Astrocytes are key homeostasis cells of the central nervous system, which are essential for normal neuronal development, function, metabolism and response to injury and inflammation, and play an indispensable role in the physiological and pathological processes of the central nervous system.Recently, studies have found that astrocytes are activated into at least two different phenotypes of reactive astrocytes after disease or stimulus, namely A1(proinflammatory) phenotype or A2 protective(anti-inflammatory) phenotype.Each phenotype of astrocyte plays different role at different time after craniocerebral injury.This article focuses on the classification, function, expression time and mechanism of reactive astrocytes after traumatic brain injury.

关 键 词：创伤性颅脑损伤 A1/A2型星形胶质细胞 时间推断 综述 

分 类 号：R89[医药卫生—法医学]