不同水平程序性细胞死亡因子5对重症流行性感冒患者病情的影响  

Effects of PDCD5 on the patients with severe influenza

作　　者：李明[1] 苏维[2] 马士恒[1] 王涛[3] LI Ming;SU Wei;MA Shiheng;WANG Tao(Department of Infectious Disease, Affiliated Hospital of Hebei University, Baoding 071000,China;Department of Clinical Laboratory, Affiliated Hospital of Hebei University, Baoding 071000,China;Tuberculosis Department, Affiliated Hospital of Hebei University, Baoding 071000,China)

机构地区：[1]河北大学附属医院感染疾病科,河北保定071000 [2]河北大学附属医院检验科,河北保定071000 [3]河北大学附属医院结核科,河北保定071000

出　　处：《医学研究与教育》2022年第2期10-15,共6页Medical Research and Education

基　　金：保定市科学技术研究与发展计划项目(2041ZF182);河北大学附属医院青年基金项目(2015Q008)。

摘　　要：目的分析不同血清水平程序性细胞死亡因子5(programmed cell death 5,PDCD5)的流行性感冒(简称流感)患者临床并发症情况以及重症流感患者的影响因素。方法选择2020年6月至12月在河北大学附属医院就诊的流感患者104例作为研究对象,按照入院时血清PDCD5是否大于10μg/L分为HP组(PDCD5>10μg/L,n=38)和LP组(PDCD5≤10μg/L,n=66),分析2组呼吸衰竭、心肌炎、多脏器功能衰竭(multiple organ dysfunction syndrome,MODS)发生情况。按照病情严重程度分级标准分为轻症组(n=61)和重症组(n=43),比较2组的一般资料及临床资料,应用多因素Logistic回归分析影响重症患者的独立危险因素。结果HP组的呼吸衰竭、心肌炎、MODS发生率均高于LP组(P<0.05)。单因素分析显示,重症组与轻症组的体质量指数、吸烟史、慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)、基质金属蛋白酶9(matrix metalloproteinase 9,MMP9)、氧和指数、淋巴细胞计数、淋巴细胞亚群以及PDCD5水平差异有统计学意义(P<0.05)。多因素Logistic回归分析显示,患者低淋巴细胞计数和CD4^(+)T细胞计数、高降钙素原(procalcitonin,PCT)以及PDCD5>10μg/L是患重型流感的独立危险因素(P<0.05)。结论淋巴细胞、CD4^(+)T淋巴细胞和PDCD5、PCT可能影响流感患者的病情,流感患者的诊治过程中应重视上述指标。Objective To analyze the clinical complications of patients with influenza pneumonia in different PDCD5 levels and the risk factors of severe influenza patients.Methods 104 patients with influenza treated in ourhospital from June 2020 to December 2020 were divided into HP group(PDCD5>10μg/L,n=38)and LP group(PDCD5≤10μg/L,n=66).They were divided into mild disease group(n=61)and severe disease group(n=43)according to the severity.The incidence of respiratory failure,cardiac myositis and multiple organ failure(MODS)were analyzed.The general and clinical data of the two groups were compared,and the independent risk factors of severe patients were analyzed with multivariate logistic regression.Results The incidence of respiratory failure,myocarditis and MODS in HP group were higher than those in LP group(P<0.05).Univariate analysis showed that there were significant differences between severe group and mild group in BMI,smoking history,COPD,MMP9,PaO2/FiO2,lymphocyte,lymphocyte subsets and PDCD5 level(P<0.05).Multivariate logistic regression analysis showed that low lymphocyte and CD4^(+)T cell,high PCT and PDCD5>10μg/L were independent risk factors for patients with severe influenza(P<0.05).Conclusion Lymphocytes,CD4^(+)T lymphocytes,PDCD5 and PCT may affect the disease progression and more attention should be paid to those indexes.

关 键 词：流行性感冒 程序性细胞死亡分子5 淋巴细胞亚群 降钙素原 

分 类 号：R51[医药卫生—内科学]