红细胞血型Cromer抗原研究进展  

Advances in research of erythrocyte blood group Cromer antigen

作　　者：王鹤[1] 李树中(审校)[1] 李中华 田丰 徐良 朱敏[1] WANG He;LI Shuzhong;LI Zhonghua

机构地区：[1]江苏大学附属昆山医院,江苏昆山215300 [2]牡丹江市第二人民医院 [3]昆山市第三人民医院

出　　处：《临床血液学杂志》2022年第2期149-153,共5页Journal of Clinical Hematology

摘　　要：CROM抗原是一种直接链接在红细胞膜外GPI上的抗原,近年来CROM抗原的研究有了许多新进展和发现,本文就目前国内外的一些研究报道,做一简略综述。1 基因CROM抗原的基因位点在1号染色体长臂3区2带;1q32.2,基因名:CROM/DAF或CD55,基因长:46 495 bp, 基因编号:1604,基因库注册号:NG;07465.1(DNA基因组),基因有10个外显子(图1)。CROM antigen is a kind of expression in GPI blood group antigen on the cell membrane, is Ⅳ transmembrane protein, also known as the decay accelerating factor(DAF), complement regulatory proteins, and membrane CD55 differentiation antigens. The peptide chain has four ring-folded structures in which all CROM antigens are expressed. The main function of CROM glycoprotein is to regulate the complement system to protect host cells and tissues from damage by controlling the amount of complement C3 and adjusting the amount of inhibiting the production of C5. CROM antigens are polymorphic and missense mutations lead to different antigenicity expressions. CROM antigens can trigger a mild transfusion hemolysis.

关 键 词：CROM抗原 补体调节蛋白 衰变加速因子 膜分化抗原 输血反应 

分 类 号：R457.1[医药卫生—治疗学]