中医调周法联合生酮饮食治疗肾虚痰湿型多囊卵巢综合征临床观察  

Research on the Effect of Traditional Chinese Medicine-Based Regulation of Menstrual Cycle Combined with Ketogenic Diet on the Polycystic Ovary Syndrome of Kidney Deficiency and Phlegm-dampness Type

作　　者：梁未雯 赵永新 周英[2] 吴士英 李连兄 姜和平 刘瑞 裴小娟 LIANG Weiwen;ZHAO Yongxin;ZHOU Ying;WU Shiying;LI Lianxiong;JIANG Heping;LIU Rui;PEI Xiaojuan(Gynecology Department,Qinghai Maternal and Child Health Care Hospital,Qinghai Province,Xining 810007,China;Gynecology Department,the First Affiliated Hospital of Guangzhou University of Chinese Medicine,Guangdong Province,Guangzhou 510405,China)

机构地区：[1]青海省妇幼保健院妇科,青海西宁810007 [2]广州中医药大学第一附属医院妇科,广东广州510405

出　　处：《光明中医》2022年第7期1126-1129,共4页GUANGMING JOURNAL OF CHINESE MEDICINE

基　　金：青海省中藏医药(循证)研究课题项目(No.2019103)。

摘　　要：目的研究中医调周法联合生酮饮食对肾虚痰湿型多囊卵巢综合征(PCOS)患者生育功能的影响。方法选择2019年8月—2020年6月就诊于青海省妇幼保健院妇科门诊,确诊为PCOS的患者,共80例。随机分为中医调周法联合生酮饮食组、中医调周法组、生酮饮食组、来曲唑组,观察疗程为3个月经周期,观察4组患者治疗前后体质量指数(BMI)、血清性激素(FSH、LH)、AMH、子宫内膜厚度、子宫动脉血流的搏动指数(PI)和阻力指数(RI)以及2组患者治疗后周期优卵泡数、周期排卵率、妊娠率、早期流产率的情况。结果治疗后,中医调周法联合生酮饮食组BMI、LH、AMH改善均明显优于中医调周组、生酮饮食组、来曲唑组(P<0.05),血清FSH升高不明显(P>0.05);中医调周法联合生酮饮食组妊娠率较高,差异有统计学意义(P<0.05)。结论中医调周法联合生酮饮食可调节PCOS患者紊乱的性激素及AMH水平,改善患者BMI水平,显著提高妊娠率。Objective To investigate the effects of traditional Chinese medicine(TCM)-based regulation of menstrual cycle combined with ketogenic diet on the female reproductive system in patients with polycystic ovary syndrome(PCOS)of kidney deficiency and phlegmdampness type.Methods Eighty patients who visited the outpatient clinic of the gynecology department of Qinghai Provincial Maternity and Child-Care Hospital and diagnosed with PCOS between August 2019 and June 2020 were enrolled and randomly assigned to four groups respectively treated with TCM-based regulation of menstrual cycle combined with ketogenic diet(MCR-KD group),TCM-based regulation of menstrual cycle alone(MCR group),ketogenic diet(KD group),and letrozole(letrozole group)for three menstrual cycles(i.e.,three months).The pre-treatment and post-treatment levels of body mass index(BMI),serum follicle stimulating hormone(FSH),serum luteinizing hormone(LH),anti-Mullerian hormone(AMH),endometrial thickness(EMT),pulsatility index(PI)and resistance index(RI)in the four groups were observed.At the end of the treatment program,a comparative analysis was conducted to evaluate the effects of different treatment options on the number of periodic optimal follicles,ovulation rate,pregnancy rate,and early spontaneous abortion rate in PCOS patients.Results The post-treatment levels of BMI,LH,and AMH were significantly improved in the MCR-KD group in comparison with the rest three groups(P<0.05),although the serum FSH level was increased in the MCR-KD group,but the difference lacked statistical significance(P>0.05).The MCR-KD group had a significantly higher pregnancy rate compared with the rest three groups(P<0.05).Conclusions TCM-based regulation of menstrual cycle combined with ketogenic diet is beneficial to PCOS patients by improving sex hormone disorders,fluctuations in AMH,BMI,and the pregnancy rate.

关 键 词：中医调周法 生酮饮食 多囊卵巢综合征 不孕 

分 类 号：R271.9[医药卫生—中西医结合]