某院住院患者碳青霉烯类耐药的肺炎克雷伯菌的临床分布及其耐药性分析  

Analysis of Clinical Distribution and Drug Resistance of Carbapenem-resistant Klebsiella Pneumoniae in Hospitalized Patients of a Hospital

作　　者：王静 王媛媛[2] 穆燕莉 WANG Jing;WANG yuan-yuan;MU Yan-li(Luoyang Hospital of Traditional Chinese Medicine,L uoyang Henan 471000,China;The No.l Hospital Affiliated to Henan University of Science and Technology,Luoyang Henan 471000,China)

机构地区：[1]洛阳市中医院,河南洛阳471000 [2]河南科技大学第一附属医院,河南洛阳471000

出　　处：《抗感染药学》2022年第2期198-201,共4页Anti-infection Pharmacy

摘　　要：目的:分析医院住院患者碳青霉烯类耐药的肺炎克雷伯菌(carbapenems-resistant Klebsiella pneumoniae,CRKP)的临床分布与耐药特征。方法:选取2020年6月—2021年6月洛阳市中医院收治的146例CRKP感染患者作为研究对象,分析CRKP的临床分布特征及其耐药情况。结果:146例CRKP感染患者主要来自呼吸与危重症医学科(占44.52%),其次为肝胆外科、重症医学科(分别占21.23%、13.01%);患者标本主要为痰液(占43.15%),其次为血液、引流液(分别占23.29%、13.01%);药敏试验结果显示,CRKP仅对替加环素、复方磺胺甲噁唑、阿米卡星和庆大霉素的耐药率较低。结论:CRKP感染多发生于呼吸与危重症医学科患者,标本多为痰液,CRKP仅对少数抗菌药物耐药率较低,临床应严格规范抗菌药物的使用,加强对CRKP耐药监测,以减少CRKP的产生。Objective: To analyze the clinical distribution and drug resistance characteristics of carbapenems-resistant Klebsiella pneumoniae(CRKP) in hospitalized patients. Methods: A total of 146 patients with CRKP infection admitted to Luoyang Hospital of Traditional Chinese Medicine from June 2020 to June 2021 were selected to analyze the clinical distribution characteristics and drug resistance of CRKP. Results: The 146 patients with CRKP infection were mainly from respiratory ICU(44.52%), followed by department of hepatobiliary surgery(21.23%) and ICU(13.01%). The main specimens were sputum(43.15%), followed by blood and drainage fluid(23.29% and 13.01%,respectively). The results of drug susceptible test showed that CRKP only had low drug resistance rates to tigecycline,compound sulfamethoxazole, amikacin and gentamicin. Conclusion: CRKP infection is most common in respiratory ICU patients, and CRKP is mostly isolated from sputum. CRKP has a low resistance rate to only a few antibacterial agents, so the rational use of antibacterials and resistance surveillance of CRKP should be strengthened to reduce the occurrence of CRKP.

关 键 词：碳青霉烯类耐药的肺炎克雷伯菌 耐药性 临床分布 

分 类 号：R915[医药卫生—微生物与生化药学] R969.3[医药卫生—药学]