2-(3-羧基苯甲巯基)-5-(2-吡啶基)-1,3,4-噁二唑的合成与表征  

Synthesis and Characterization of 2-(3-carboxybenzyl sulfhydryl)-5-(2-pyridyl)-1,3,4-oxadiazole

作　　者：屈树婷 于保杰 石广慧 冷宜泉 吴祥雯[1] Qu Shuting;Yu Baojie;Shi Guanghui;Leng Yiquan;Wu Xiangwen(College of Chemistry,Chemical Engineering and Materials Science,Shandong Normal University,Jinan 250014,China)

机构地区：[1]山东师范大学化学化工与材料科学学院,山东济南250014

出　　处：《山东化工》2022年第9期30-32,共3页Shandong Chemical Industry

基　　金：山东师范大学大学生创新创业训练计划项目(S202010445131);山东师范大学大型仪器设备开放基金(KFJJ2018011)。

摘　　要：以2-吡啶甲酸乙酯为起始原料经系列反应得中间体2-吡啶甲酰肼、2-(2-吡啶基)-5-巯基-1,3,4-噁二唑,最后与制得的间溴甲基苯甲酸经Williamson反应得目标产物2-(3-羧基苯甲巯基)-5-(2-吡啶基)-1,3,4-噁二唑,并用核磁共振氢谱和红外光谱对结构予以表征。In this paper,ethyl 2-picolinate was used as a starting material to obtain intermediate 2-pyridinium hydrazide,2-(2-pyridyl)-5-sulfhydryl-1,3,4-oxadiazol after a series of reactions.2-(2-pyridyl)-5-sulfhydryl-1,3,4-oxadiazol was finally reacted with m-bromomethyl benzoic acid to get the target product 2-(3-carboxybenzyl sulfhydryl)-5-(2-pyridyl)-1,3,4-oxadiazole.The final product was characterized by 1H-NMR and IR spectroscopy.

关 键 词：噁二唑 不对称配体 配位化学 

分 类 号：TQ252.4[化学工程—有机化工]