姜黄素脂质体药物动力学研究进展  

Progress in the Pharmacokinetics of Curcumin Liposomes

作　　者：王向楠 李佳 张强[1] 程岚[1] 张纯刚 Wang Xiangnan;Li Jia;Zhang Qiang;Cheng Lan;Zhang Chungang(College of Pharmacy,Liaoning University of Traditional Chinese Medicine,Dalian 116620,China;Department of Pharmacy,Changzhi Medical College,Changzhi 046000,China)

机构地区：[1]辽宁中医药大学药学院,辽宁大连116620 [2]长治医学院药学系,山西长治046000

出　　处：《山东化工》2022年第9期70-72,共3页Shandong Chemical Industry

基　　金：中医脏象理论及应用国家教育部重点实验室一般项目(No.zyzx1809);辽宁省科学计划-自然基金指导计划(No.2019-ZD-0968);沈阳市中青年科技创新人才项目(RC200204);辽宁中医药大学2020年度大学生创新创业训练计划立项项目(X202010162044)。

摘　　要：近年来,姜黄素由于其优异的生理活性在医药领域受到广泛关注,但姜黄素水溶性差、代谢迅速、生物利用度低等缺陷影响了其发展应用,因此许多提高姜黄素生物利用度的制剂应运而生。脂质体作为一种优异的负载材料,已被广泛应用于姜黄素的制备。本文对近几年姜黄素脂质体的相关文献进行整理,总结脂质体中姜黄素的分析方法及药物动力学参数等相关数据,对姜黄素脂质体药物动力学研究进行综述,以期为姜黄素脂质体的后续研究提供参考。In recent years,curcumin has attracted wide attention in the pharmaceutical field due to its excellent physiological activities,but its poor water solubility,rapid metabolism and low bioavailability have affected its development and application,so,many preparations to improve curcumin bioavailability have emerged.Liposomes,as an excellent loading material,have been widely used for the preparation of curcumin.In this paper,we compiled the relevant literature on curcumin liposomes in recent years,summarized the analytical methods and pharmacokinetic parameters of curcumin in liposomes and other related data,reviewed the pharmacokinetic studies on curcumin liposomes,in order to providing references for the subsequent studies on curcumin liposomes.

关 键 词：姜黄素 脂质体 药物动力学 生物利用度 

分 类 号：TQ460[化学工程—制药化工] R283[医药卫生—中药学]