重组人脑利钠肽联合呋塞米治疗急性左心衰的疗效观察  

Efficacy of recombinant human brain natriuretic peptide combined with furosemide in the treatment of acute left heart failure

作　　者：于长宏 YU Chang-hong(Department of Cardiology,Dandong People’s Hospital,Dandong 118000,China)

机构地区：[1]丹东市人民医院心血管科,118000

出　　处：《中国现代药物应用》2022年第6期88-90,共3页Chinese Journal of Modern Drug Application

摘　　要：目的分析急性左心衰疾病特点,评价重组人脑利钠肽与呋塞米联合治疗的预后效果。方法84例急性左心衰患者,随机分为对照组及观察组,每组42例。对照组患者采取呋塞米治疗,观察组患者在对照组基础上辅助重组人脑利钠肽治疗。比较两组患者临床疗效、不良反应反应发生情况及治疗前后的左心室射血分数(LVEF)、N末端B型利钠肽前体(NT-proBNP)水平。结果观察组患者治疗总有效率97.62%高于对照组的83.33%,不良反应发生率2.38%低于对照组的19.05%,差异具有统计学意义(P<0.05)。治疗后,观察组患者LVEF水平(46.85±6.50)%高于对照组的(37.50±6.20)%,NTproBNP水平(2970.50±500.50)ng/L低于对照组的(4125.50±400.50)ng/L,差异具有统计学意义(P<0.05)。结论重组人脑利钠肽联合呋塞米治疗急性左心衰具有安全性、有效性价值,有助于改善患者心功能、肾功能。Objective To analyze the characteristics of acute left heart failure and evaluate the prognostic effect of the combination therapy of recombinant human brain natriuretic peptide and furosemide.Methods A total of 84 patients with acute left heart failure were randomly divided into control group and observation group,with 42 cases in each group.Patients in the control group were treated with furosemide,and patients in the observation group were treated with recombinant human brain natriuretic peptide on the basis of the control group.The clinical efficacy,occurrence of adverse reactions,left ventricular ejection fraction(LVEF)and N-terminal pro-B-type natriuretic peptide(NT-proBNP)levels before and after treatment were compared between the two groups.Results The total effective rate 97.62% in the observation group was higher than 83.33% in the control group,and the incidence of adverse reactions 2.38% was lower than 19.05% in the control group,and the difference was statistically significant(P<0.05).After treatment,the LVEF(46.85±6.50)% of the observation group was higher than(37.50±6.20)% of the control group,and the NT-proBNP(2970.50±500.50)ng/L was lower than(4125.50±400.50)ng/L of the control group.All the differences were statistically significant(P<0.05).Conclusion Recombinant human brain natriuretic peptide combined with furosemide has safety and effectiveness in the treatment of acute left heart failure,which can help improve the patient’s heart and kidney function.

关 键 词：重组人脑利钠肽 呋塞米 急性左心衰 治疗效果 不良反应 心肾功能 

分 类 号：R541.6[医药卫生—心血管疾病]