胸腺五肽联合纤维支气管镜药物灌注治疗肺结核患者的临床效果及对免疫功能的影响  

Effects of thymopentin combined with drug perfusion through fiberoptic bronchoscope on clinical outcome and immunologic function in patients with pulmonary tuberculosis

作　　者：田茜[1] TIAN Qian(Shenyang Chest Hospital,Shenyang 110044,China)

机构地区：[1]沈阳市胸科医院,110044

出　　处：《中国现代药物应用》2022年第6期111-114,共4页Chinese Journal of Modern Drug Application

摘　　要：目的探究胸腺五肽联合纤维支气管镜药物灌注治疗肺结核患者的临床效果及对免疫功能的影响。方法113例肺结核患者,根据治疗方式不同分为观察组(59例)和对照组(54例)。对照组患者进行基本治疗,观察组患者在对照组基础上使用胸腺五肽联合纤维支气管镜药物灌注治疗。比较两组患者临床疗效、治疗前后T淋巴免疫细胞水平及治疗前后炎性因子[白细胞介素-10(IL-10)、干扰素-γ(IFN-γ)、转化生长因子-β_(1)(TGF-β_(1))]水平。结果观察组患者的治疗总有效率为96.61%,明显高于对照组的85.19%,差异具有统计学意义(P<0.05)。治疗前,两组患者的CD3^(+)、CD4^(+)、CD8^(+)和CD4^(+)/CD8^(+)比较差异无统计学意义(P>0.05);治疗后,观察组患者的CD3^(+)(50.64±4.56)%、CD4^(+)(38.53±4.41)%和CD4^(+)/CD8^(+)(1.71±0.14)均明显高于于对照组的(47.03±4.28)%、(31.24±4.26)%、(1.33±0.12),CD8^(+)(30.65±5.03)%明显低于对照组的(36.24±4.82)%,差异具有统计学意义(P<0.05)。治疗前,两组患者的IL-10、IFN-γ、TGF-β_(1)比较差异无统计学意义(P>0.05);治疗后,观察组患者的IL-10、TGF-β_(1)均明显低于对照组,IFN-γ明显高于对照组,差异具有统计学意义(P<0.05)。结论肺结核患者采用胸腺五肽联合纤维支气管镜药物灌注治疗有较好的效果,可以显著降低患者的炎症水平,并提高免疫力,值得临床推广使用。Objective To investigate the effects of thymopentin combined with drug perfusion through fiberoptic bronchoscope on clinical outcome and immunologic function in patients with pulmonary tuberculosis.Methods 113 patients with pulmonary tuberculosis were divided into the observation group(59 cases)and the control group(54 cases)according to different treatment methods.Patients in the control group received basic treatment,and patients in the observation group received thymopentin combined with drug perfusion through fiberoptic bronchoscope in addition to the treatment of the control group.The clinical efficacy,levels of T-lymphocyte and inflammatory factors[interleukin-10(IL-10)and interferon-γ(IFN-γ),transforming growth factor-β_(1)(TGF-β_(1))]before and after the treatment were compared between the two groups.Results The overall efficacy of the observation group was 96.61%,which was significantly higher than 85.19%of the control group,and the difference was statistically significant(P<0.05).Before the treatment,the differences in CD3^(+),CD4^(+),CD8^(+)and CD4^(+)/CD8^(+)between the two groups were not statistically significant(P>0.05).After the treatment,the observation group had CD3^(+)of(50.64±4.56)%,CD4^(+)of(38.53±4.41)% and CD4^(+)/CD8^(+)of(1.71±0.14),which were significantly higher than(47.03±4.28)%,(31.24±4.26)%,(1.33±0.12)of the control group,respectively;CD8^(+)of the observation group was(30.65±5.03)%,which was significantly lower than(36.24±4.82)% of the control group;and the differences were statistically significant(P<0.05).Before the treatment,the differences in IL-10,IFN-γ,TGF-β_(1) between the two groups were not statistically significant(P>0.05).After the treatment,IL-10 and TGF-β_(1) of the observation group were significantly lower than those of the control group,IFN-γ of the observation group was significantly higher than that of the control group,and the differences were statistically significant(P<0.05).Conclusion Application of thymopentin combined with drug perfusion throu

关 键 词：胸腺五肽 纤维支气管镜 肺结核 免疫功能 

分 类 号：R521[医药卫生—内科学]