异种心脏移植与无线心室辅助装置  

Cardiac xenotransplantation and wireless left ventricular assist device

作　　者：刘金平 张力[1] LIU Jinping;ZHANG Li(Department of Cardiovascular Surgery,Zhongnan Hospital of Wuhan University,Wuhan,430060,China)

机构地区：[1]武汉大学中南医院心血管外科,武汉430060

出　　处：《临床心血管病杂志》2022年第4期261-264,共4页Journal of Clinical Cardiology

基　　金：国家自然科学基金项目(No:82100412);湖北省重点研发计划(No:2020BCB053)。

摘　　要：心力衰竭(心衰)日益成为人类健康的主要威胁,供体器官的缺乏以及常规心室辅助装置的负担,使心衰的治疗难以兼顾患者的生存率和生活质量。近年来,在基因编辑技术的推动下,异种心脏移植克服了免疫排斥、凝血功能失调、炎症及缺血再灌注损伤以及猪内源性逆转录病毒等多重障碍;同时随着医疗器械技术的进步,心室辅助装置逐步实现微型化、无线化。这些技术的进步将为心衰患者提供新的治疗策略。Heart failure is increasingly becoming a major threat to human health.Due to the lack of donor organs and the burden of conventional ventricular assist devices,it is difficult to pursue both the survival rate and quality of life of patients in treating heart failure.In recent years,driven by gene-editing technology,cardiac xenotransplantation has overcome multiple barriers,such as immune rejection,coagulation dysfunction,inflammation and ischemia-reperfusion injury,and porcine endogenous retroviruses.At the same time,with the advancement of medical device technology,ventricular assist devices have gradually achieved miniaturization and wireless.These technological advances will provide new treatment strategies for patients with heart failure.

关 键 词：心力衰竭 异种心脏移植 心室辅助装置 

分 类 号：R541.6[医药卫生—心血管疾病]