中国双生子人群2型糖尿病分布特征  

A descriptive analysis on type 2 diabetes in twins in China

作　　者：郑可 高文静[1] 吕筠[1] 余灿清[1] 王胜锋[1] 黄涛 孙点剑一 廖春晓[1] 庞元捷[1] 逄增昌[2] 俞敏[3] 汪华[4] 吴先萍[5] 董忠[6] 吴凡[7] 江国虹[8] 王晓节[9] 刘彧 邓健[11] 陆林[12] 曹卫华[1] 李立明[1] Zheng Ke;Gao Wenjing;Lyu Jun;Yu Canqing;Wang Shengfeng;Huang Tao;Sun Dianjianyi;Liao Chunxiao;Pang Yuanjie;Pang Zengchang;Yu Min;Wang Hua;Wu Xianping;Dong Zhong;Wu Fan;Jiang Guohong;Wang Xiaojie;Liu Yu;Deng Jian;Lu Lin;Cao Weihua;Li Liming(Department of Epidemiology and Biostatistics,School of Public Health,Peking University,Beijing 100191,China;Qingdao Municipal Center for Disease Control and Prevention,Qingdao 266033,China;Zhejiang Provincial Center for Disease Control and Prevention,Hangzhou 310051,China;Jiangsu Provincial Center for Disease Control and Prevention,Nanjing 210009,China;Sichuan Provincial Center for Disease Control and Prevention,Chengdu 610041,China;Beijing Center for Disease Prevention and Control,Beijing 100013,China;Shanghai Municipal Center for Disease Control and Prevention,Shanghai 200336,China;Tianjin Centers for Disease Control and Prevention,Tianjin 300011,China;Qinghai Center for Diseases Prevention and Control,Xining 810007,China;Heilongjiang Provincial Center for Disease Control and Prevention,Harbin 150090,China;Handan Center for Disease Control and Prevention,Handan 056001,China;Yunnan Center for Disease Control and Prevention,Kunming 650034,China)

机构地区：[1]北京大学公共卫生学院流行病与卫生统计学系,北京100191 [2]青岛市疾病预防控制中心,青岛266033 [3]浙江省疾病预防控制中心,杭州310051 [4]江苏省疾病预防控制中心,南京210009 [5]四川省疾病预防控制中心,成都610041 [6]北京市疾病预防控制中心,北京100013 [7]上海市疾病预防控制中心,上海200336 [8]天津市疾病预防控制中心,天津300011 [9]青海省疾病预防控制中心,西宁810007 [10]黑龙江省疾病预防控制中心,哈尔滨150090 [11]邯郸市疾病预防控制中心,邯郸056001 [12]云南省疾病预防控制中心,昆明650034

出　　处：《中华流行病学杂志》2022年第5期634-640,共7页Chinese Journal of Epidemiology

基　　金：公益性行业科研专项(201502006,201002007)。

摘　　要：目的描述中国双生子登记系统(CNTR)双生子的2型糖尿病分布特征,为揭示遗传和环境因素对2型糖尿病的影响提供线索和依据。方法CNTR 2010-2018年项目登记的所有双生子中,纳入≥30岁且有完整登记信息的18855对双生子作为研究对象。采用随机效应模型描述2型糖尿病的人群、地区分布特征以及对内一致性的分布。结果研究对象年龄(42.8±10.2)岁,同卵双生子(MZ)10339对,异卵双生子(DZ)8516对。全人群中2型糖尿病报告患病率为2.2%,MZ和DZ报告患病率差异无统计学意义。双生子对内分析发现2型糖尿病MZ同病率为38.2%,DZ为16.0%,差异有统计学意义(P<0.001),在不同性别、年龄和地区中MZ同病率均大于DZ(P<0.05)。进一步分层分析,在北方,仅在<60岁人群中发现MZ同病率大于DZ(P<0.05);而南方,≥60岁男性MZ同病率也大于DZ(P<0.05)。结论本研究的双生子人群2型糖尿病报告患病率低于一般人群,在不同性别、年龄和地区中均提示遗传因素在2型糖尿病中起作用,但其作用大小可能不尽相同。Objective To describe the distribution characteristics of type 2 diabetes in twins in Chinese National Twin Registry(CNTR),provide clues and evidence for revealing the influence of genetic and environmental factors for type 2 diabetes.Methods Of all twins registered in the CNTR during 2010-2018,a total 18855 twin pairs aged≥30 years with complete registration information were included in the analysis.The random effect model was used to describe the population and area distribution characteristics and concordance of type 2 diabetes in twin pairs.Results The mean age of the subjects was(42.8±10.2)years,the study subjects included 10339 monozygotic(MZ)twin pairs and 8516 dizygotic(DZ)twin pairs.The self-reported prevalence rate of type 2 diabetes was 2.2%in total population and there was no sighificant difference between MZ and DZ.Intra-twin pairs analysis showed that the concordance rate of type 2 diabetes was 38.2%in MZ twin pairs,and 16.0%in DZ twin pairs,the difference was statistically significant(P<0.001).The concordance rate of type 2 diabetes in MZ twin parts was higher than that in DZ twin pairs in both men and women,in different age groups and in different areas(P<0.05).Further stratified analysis showed that in northern China,only MZ twin pairs less than 60 years old were found to have a higher concordance rate of type 2 diabetes compared with DZ twin pairs(P<0.05).In southern China,the co-prevalence rate in male MZ twin pairs aged≥60 years was still higher than that in DZ twin pairs(P<0.05).Conclusion The twin pairs in this study had a lower self-reported prevalence of type 2 diabetes than the general population.The study results suggested that genetic factors play a role in type 2 diabetes prevalence in both men and women,in different age groups and in different areas,however,the effect might vary.

关 键 词：糖尿病 2型 双生子研究 同病率 现况研究 

分 类 号：R587.1[医药卫生—内分泌]