探究中国双生子人群中的冠心病遗传生活方式交互作用  

Gene-lifestyle interaction on coronary heart disease in adult twins of China

作　　者：奚玉娥 高文静[1] 吕筠[1] 余灿清[1] 王胜锋[1] 黄涛 孙点剑一 廖春晓[1] 庞元捷[1] 逄增昌[2] 俞敏[3] 汪华[4] 吴先萍[5] 董忠[6] 吴凡[7] 江国虹[8] 王晓节[9] 刘彧 邓健[11] 陆林[12] 曹卫华[1] 李立明[1] Xi Yu'e;Gao Wenjing;Lyu Jun;Yu Canqing;Wang Shengfeng;Huang Tao;Sun Dianjianyi;Liao Chunxiao;Pang Yuanjie;Pang Zengchang;Yu Min;Wang Hua;Wu Xianping;Dong Zhong;Wu Fan;Jiang Guohong;Wang Xiaojie;Liu Yu;Deng Jian;Lu Lin;Cao Weihua;Li Liming(Department of Epidemiology and Biostatistics,School of Public Health,Peking University,Beijing 100191,China;Qingdao Municipal Center for Disease Control and Prevention,Qingdao 266033,China;Zhejiang Provincial Center for Disease Control and Prevention,Hangzhou 310051,China;Jiangsu Provincial Center for Disease Control and Prevention,Nanjing 210009,China;Sichuan Provincial Center for Disease Control and Prevention,Chengdu 610041,China;Beijing Center for Disease Prevention and Control,Beijing 100013,China;Shanghai Municipal Center for Disease Control and Prevention,Shanghai 200336,China;Tianjin Centers for Disease Control and Prevention,Tianjin 300011,China;Qinghai Center for Diseases Prevention and Control,Xining 810007,China;Heilongjiang Provincial Center for Disease Control and Prevention,Harbin 150090,China;Handan Center for Disease Control and Prevention,Handan 056001,China;Yunnan Center for Disease Control and Prevention,Kunming 650034,China)

机构地区：[1]北京大学公共卫生学院流行病与卫生统计学系,北京100191 [2]青岛市疾病预防控制中心,青岛266033 [3]浙江省疾病预防控制中心,杭州310051 [4]江苏省疾病预防控制中心,南京210009 [5]四川省疾病预防控制中心,成都610041 [6]北京市疾病预防控制中心,北京100013 [7]上海市疾病预防控制中心,上海200336 [8]天津市疾病预防控制中心,天津300011 [9]青海省疾病预防控制中心,西宁810007 [10]黑龙江省疾病预防控制中心,哈尔滨150090 [11]邯郸市疾病预防控制中心,邯郸056001 [12]云南省疾病预防控制中心,昆明650034

出　　处：《中华流行病学杂志》2022年第5期649-654,共6页Chinese Journal of Epidemiology

基　　金：国家自然科学基金(81973126,81711530051);公益性行业科研专项(201502006,201002007)。

摘　　要：目的分析中国成年双生子人群的冠心病遗传-生活方式交互作用。方法利用中国双生子登记系统募集的研究对象,构建单变量交互作用模型,通过分析生活方式对冠心病遗传效应的效应修饰作用,探索冠心病的遗传-生活方式交互作用。结果本研究共纳入20477对≥25岁的同性别双生子,含395例冠心病患者,其中66对双生子均患冠心病。调整年龄和性别后,当前吸烟、当前饮酒、体力活动和蔬果摄入等生活方式对冠心病的遗传效应均没有修饰作用(均P>0.05)。结论在本研究的中国成年双生子人群中未发现冠心病的遗传-生活方式交互作用。Objective To explore the gene-lifestyle interaction on coronary heart disease(CHD)in adult twins of China.Methods Participants were selected from twin pairs registered in the Chinese National Twin Registry(CNTR).Univariate interaction model was used to estimate the interaction,via exploring the moderation effect of lifestyle on the genetic variance of CHD.Results A total of 20477 same-sex twin pairs aged≥25 years were recruited,including 395 CHD cases,and 66 twin pairs both had CHD.After adjustment for age and sex,no moderation effects of lifestyles,including current smoking,current drinking,physical activity,intake of vegetable and fruit,on the genetic variance of CHD were found(P>0.05),suggesting no significant interactions.Conclusion There was no evidence suggesting statistically significant gene-lifestyle interaction on CHD in adult twins of China.

关 键 词：冠心病 生活方式 遗传-环境交互作用 双生子研究 

分 类 号：R541.4[医药卫生—心血管疾病]