健脾祛湿汤加减联合二甲双胍治疗糖尿病的效果分析  

Effect of Jianpi Damshi Decoction combined with Metformin on diabetes mellitus

作　　者：冯修江 卢显英 许长枕 FENG Xiujiang;LU Xianying;XU Changzhen(Department I of Internal Medicine,Nanxiong Hospital of Traditional Chinese Medicine,Nanxiong,Guangdong 512400,China;Department of Public Health Community Health Service Center of Xiongzhou Street,Nanxiong,Guangdong 512400,China)

机构地区：[1]南雄市中医院内一科,广东南雄512400 [2]南雄市雄州街道社区卫生服务中心公卫科,广东南雄512400

出　　处：《医药前沿》2022年第11期4-7,共4页Journal of Frontiers of Medicine

基　　金：韶关市卫生健康科研项目(Y20025)。

摘　　要：目的:探究健脾祛湿汤加减联合二甲双胍治疗糖尿病的效果。方法:选取南雄市中医院2019年7月—2021年10月期间接诊的92例糖尿病患者,按照随机数字表法分为对照组与观察组各46例。对照组单独使用二甲双胍治疗,观察组在对照组治疗基础上联合使用健脾祛湿汤加减治疗,疗程为6个月。对比两组临床效果。其观察指标包括:总有效率、血糖(空腹血糖、餐后2 h血糖、糖化血红蛋白)、血脂(三酰甘油、低密度脂蛋白胆固醇)水平及不良反应等。结果:用药6个月后,观察组总有效率(91.30%)显著高于对照组(69.57%),差异有统计学意义(P<0.05);观察组空腹血糖、餐后2 h血糖、糖化血红蛋白、三酰甘油、低密度脂蛋白胆固醇水平显著低于对照组,差异有统计学意义(P<0.05);观察组中医症候积分显著低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:对糖尿病患者予以健脾祛湿汤加减联合二甲双胍方案,可强化血糖控制效果,调节糖脂代谢,缓解临床症状,保证患者用药安全性,值得临床应用。Objective To explore the effect and adverse reactions of Jianpi Damshi Decoction combined with Metformin in the treatment of diabetes.Methods 92 patients with diabetes received from July 2019 to October 2021 in Nanxiong Hospital of traditional Chinese medicine were randomly divided into control group and observation group with 46 cases in each group.The control group was treated with metformin alone,and the observation group was treated with Jianpi Qushi Decoction on the basis of the control group.The course of treatment was 6 months.The clinical effects of the two groups were compared,including total effective rate,blood glucose(fasting blood glucose,2-hour postprandial blood glucose,glycosylated hemoglobin)and blood lipid(triacylglycerol,low density lipoprotein cholesterol)levels,adverse reactions,etc.Results After 6 months of treatment,the total effective rate of the observation group(91.30%)was significantly higher than that of the control group(69.57%)(P<0.05);The levels of fasting blood glucose,2 h postprandial blood glucose,glycosylated hemoglobin,triacylglycerol and low density lipoprotein cholesterol in the observation group were significantly lower than those in the control group(P<0.05);The score of TCM symptoms in the observation group was significantly lower than that in the control group(P<0.05);There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Strengthening the spleen and eliminating dampness decoction combined with metformin in diabetic patients can enhance the effect of blood glucose control,regulate the metabolism of glucose and lipid,relieve clinical symptoms,and ensure the safety of medication.

关 键 词：糖尿病 健脾祛湿汤加减 二甲双胍 

分 类 号：R587.1[医药卫生—内分泌]