帕夫林联合羟氯喹治疗干燥综合征的效果观察  

Effect of Pavlin combined with Hydroxychloroquine in the treatment of Sjogren’s syndrome

作　　者：徐连那 庞琳娜 李旭艳 XU Lianna;PANG Linna;LI Xuyan(Department of Rheumatology and Immunology,Shijingshan Teaching Hospital of Capital Medical University,Beijing 100040,China)

机构地区：[1]首都医科大学石景山教学医院<北京市石景山医院>风湿免疫科,北京100040

出　　处：《医药前沿》2022年第11期15-17,21,共4页Journal of Frontiers of Medicine

摘　　要：目的:观察帕夫林与羟氯喹联合治疗干燥综合征的效果。方法:选取2019年1月—2020年1月北京市石景山医院风湿免疫科接诊的干燥综合征患者100例,采用随机数字表法分为对照组和研究组各50例。研究组给予帕夫林和羟氯喹联合治疗,对照组给予羟氯喹治疗。对比两组治疗效果。结果:治疗后,研究组饮水量(0.71±0.12)L少于对照组(1.01±0.15)L,差异有统计学意义(P<0.05);研究组类风湿因子和C反应蛋白水平及血清γ-球蛋白水平治疗后分别是(17.13±4.28)I U/m L、(9.11±2.76)m g/d l、(15.62±2.13)%,低于对照组的(27.94±5.83)IU/mL、(14.82±4.37)mg/dl、(25.48±2.65)%,差异有统计学意义(P<0.05)。治疗后,研究组S c h i r m e r试验结果为2.68±0.99%,低于对照组的3.84±1.02%,差异有统计学意义(P<0.05)。治疗后,研究组D-二聚体与纤维蛋白原水平分别是(0.38±0.14)mg/L、(2.89±0.25)g/L,低于对照组的(0.76±0.19)mg/L、(3.14±0.26)g/L,差异有统计学意义(P<0.05)。治疗后,研究组活化部分凝血酶时间为(30.98±4.63)s,对照组活化部分凝血酶为时间31.48±5.12s,差异无统计学意义(P>0.05)。研究组SF-36评分为(86.42±4.19)分,高于对照组的(78.59±3.05)分,差异有统计学意义(P<0.05);研究组总有效率(98.0%)高于对照组(82.0%),差异有统计学意义(P<0.05)。结论:帕夫林和羟氯喹联合应用,在干燥综合征患者治疗中效果明显,利于临床指标改善,有助于患者生活质量的提升,值得临床应用。Objective To study the value of Pavlin combined with Hydroxychloroquine in the treatment of Sjogren’s syndrome.Methods From January 2019 to January 2020,100 patients with Sjogren’s syndrome were randomly divided into control group and study group.The study group was treated with Pavlin and Hydroxychloroquine,and the control group was treated with Hydroxychloroquine.The scores of quality of life scale(SF-36)and other indicators were compared between the two groups.Results After treatment,the amount of drinking water in the study group(0.71±0.12)was less than that in the control group(1.01±0.15),the difference was statistically significant(P<0.05);Study group rheumatoid factor and C-reactive protein levels and serumγ-After treatment,the level of globulin was(17.13±4.28)IU/mL,(9.11±2.76)mg/dl,(15.62±2.13)%,which was lower than that in the control group(27.94±5.83)IU/mL,(14.82±4.37)mg/dl,(25.48±2.65)%(P<0.05).After treatment,the result of Schirmer test in the study group was(2.68±0.99)%,which was better than that in the control group(3.84±1.02)%,and the difference was statistically significant(P<0.05).After treatment,the levels of D-dimer and fibrinogen in the study group were(0.38±0.14)mg/L and(2.89±0.25)g/L respectively,which were significantly lower than those in the control group(0.76±0.19)mg/L and(3.14±0.26)g/L(P<0.05).After treatment,the activated partial thrombin time in the study group was(30.98±4.63)s,and the activated partial thrombin time in the control group was(31.48±5.12)s.there was no significant difference(P>0.05).The score of SF-36 in the study group(86.42±4.19)was significantly higher than that in the control group(78.59±3.05)(P<0.05);The total effective rate of the study group(98.0%)was higher than that of the control group(82.0%),and the difference was statistically significant(P<0.05).Conclusion The combined application of pavlin and hydroxychloroquine has obvious effect in the treatment of patients with Sjögren’s syndrome,which is beneficial to the improvement of clinic

关 键 词：干燥综合征 帕夫林 生活质量 羟氯喹 

分 类 号：R442.8[医药卫生—诊断学]