吲哚布芬联合氯吡格雷在急性心肌梗死伴高危消化道出血风险患者中的应用效果  

Application of Indobufen Combined with Clopidogrel in Patients with Acute Myocardial Infarction and High Risk of Gastrointestinal Bleeding

作　　者：殷小金 何志华[1] 陈琦菲[1] 曾先钦 管斌亚 YIN Xiaojin;HE Zhihua;CHEN Qifei;ZENG Xianqin;GUAN Binya(Ji'an Central People's Hospital,Ji'an Jiangxi 343000,China)

机构地区：[1]吉安市中心人民医院,江西吉安343000

出　　处：《药品评价》2022年第6期348-351,共4页Drug Evaluation

基　　金：吉安市指导性科技计划项目(2020A519)。

摘　　要：目的:探讨吲哚布芬联合氯吡格雷在急性心肌梗死伴高危消化道出血风险患者中的应用效果。方法:选取2019年6月到2020年11月吉安市中心人民医院收治的高危消化道出血风险的急性心肌梗死患者60例,采用随机数字表法分两组,每组各30例,试验组予吲哚布芬+氯吡格雷治疗,对照组予阿司匹林+氯吡格雷治疗,比较两组患者有效率,凝血指标,血小板聚集率及不良反应事件发生率。结果:试验组总有效率高于对照组,差异有统计学意义(P<0.05)。治疗后,试验组的凝血酶时间(TT)、活化部分凝血活酶时间(APTT)、凝血酶原时间(PT)明显长于对照组,差异有统计学意义(P<0.05)。试验组血小板聚集率花生四烯酸(AA)、二磷酸腺苷(ADP)明显低于对照组,差异有统计学意义(P<0.05)。试验组的不良事件的发生率明显低于对照组,差异有统计学意义(P<0.05)。结论:吲哚布芬联合氯吡格雷在急性心肌梗死伴高危消化道出血风险患者中的应用可获得较为满意的抗血小板治疗效果,且安全性更高。Objective:To investigate the effect of indobufen combined with clopidogrel in patients with acute myocardial infarction and high-risk gastrointestinal bleeding.Methods:A total of 60 patients with acute myocardial infarction with high risk of gastrointestinal bleeding admiffed to Ji'an lentral People's Hospital from 2019 to November 2020 were select The patients were divided into two groups by random number table method,30 cases in each group,the experimental group was treated with indobufen+clopidogrel,the control group was treated with aspirin+clopidogrel,the effective rate,coagulation index,platelet aggregation rate and incidence of adverse events were compared between the two groups.Results:The total effective rate of the experimental group was significantly higher than that of the control group(P<0.05).After treatment,TT,APTT and PT in the experimental group were significantly longer than those in the control group(P<0.05).The platelet aggregation rates of ADP and AA in the experimental group were significantly lower than those in the control group(P<0.05).The incidence of adverse events in the experimental group was significantly lower than that in the control group(P<0.05).Conclusion:Indobufen combined with copidogrel in patients at high risk of gastrointestinal bleeding with acute myocardial infarction may have a satisfactory antiplatelet effect and a higher safety.

关 键 词：心肌梗死 胃肠出血 吲哚布芬 氯吡格雷 

分 类 号：R542.22[医药卫生—心血管疾病] R574[医药卫生—内科学]